Figures & data
Figure 1. Patient disposition and reasons for exclusion. COPD, chronic obstructive pulmonary disease; CT, computed tomography.
![Figure 1. Patient disposition and reasons for exclusion. COPD, chronic obstructive pulmonary disease; CT, computed tomography.](/cms/asset/903c6e65-0439-44ed-beb2-37dbe3378c41/icop_a_650243_f0001_b.gif)
Table 1. Baseline characteristics of the study patients (N = 42)
Table 2. Baseline characteristics of the two groups: Patients with and without a history of COPD exacerbations
Figure 2. Annual change in thoracic vertebral BMD in patients without / with a history of exacerbations. -1 Annual absolute change in thoracic vertebral BMD in patients without / with a history of exacerbations (ΔBMD (mg/ml·year): -0.30 versus -3.78, p = 0.01). -2. Annual percentage change in thoracic vertebral BMD in patients without / with a history of exacerbations based on baseline BMD. (ΔBMD/base (mg/ml·year): -0.60 versus -5.41, p = 0.02). The horizontal line is the median value, the box is the interquartile range, and the whiskers indicate the range, excluding outlying and extreme values (i.e., points with values ≥1.5 box lengths from the upper or lower limits of the box). BMD, bone mineral density; ΔBMD, annual change in thoracic BMD; ΔBMD/base, annual percentage change in BMD based on baseline BMD.
![Figure 2. Annual change in thoracic vertebral BMD in patients without / with a history of exacerbations. Figure 2-1 Annual absolute change in thoracic vertebral BMD in patients without / with a history of exacerbations (ΔBMD (mg/ml·year): -0.30 versus -3.78, p = 0.01). Figure 2-2. Annual percentage change in thoracic vertebral BMD in patients without / with a history of exacerbations based on baseline BMD. (ΔBMD/base (mg/ml·year): -0.60 versus -5.41, p = 0.02). The horizontal line is the median value, the box is the interquartile range, and the whiskers indicate the range, excluding outlying and extreme values (i.e., points with values ≥1.5 box lengths from the upper or lower limits of the box). BMD, bone mineral density; ΔBMD, annual change in thoracic BMD; ΔBMD/base, annual percentage change in BMD based on baseline BMD.](/cms/asset/79e29032-f2ad-4c7c-8405-00ca02bc6ac1/icop_a_650243_f0002_b.jpg)
Table 3. Annual changes in thoracic vertebral BMD, lung function, and LAA%
Figure 3. Annual emphysematous change represented as LAA% on CT in patients without / with a history of exacerbations. (LAA (%): 0.12 versus 1.32, p = 0.01) The horizontal line is the median value, the box is the interquartile range, and the whiskers indicate the range, excluding outlying and extreme values (i.e., points with values ≥1.5 box lengths from the upper or lower limits of the box). LAA, low attenuation area; CT, computed tomography.
![Figure 3. Annual emphysematous change represented as LAA% on CT in patients without / with a history of exacerbations. (LAA (%): 0.12 versus 1.32, p = 0.01) The horizontal line is the median value, the box is the interquartile range, and the whiskers indicate the range, excluding outlying and extreme values (i.e., points with values ≥1.5 box lengths from the upper or lower limits of the box). LAA, low attenuation area; CT, computed tomography.](/cms/asset/dd2dec01-f340-4436-a293-557d98c6943e/icop_a_650243_f0003_b.jpg)
Table 4. Univariate associations with annual change in thoracic vertebral BMD
Table 5. Stepwise multivariate regression analysis showing the relative contribution of each variable to predict the change in BMD