Figures & data
Table 1. Theoretical biomarkers of autism: gastrointestinal system.
Table 2. Theoretical biomarkers of autism: immunologic system.
Table 3. Theoretical biomarkers of autism: neurologic system.
Table 4. Theoretical biomarkers of autism: toxicologic system.
Table 5. Theoretical biomarkers of autism: ubiquitous.
Cazzullo, A.G., Musetti, M.C., Musetti, L., Bajo, S., Sacerdote, P. and Panerai, A. 1999. Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children. Eur. Neuropsychopharmacol. 9:361–366. Nelson, K.B., Grether, J.K., Croen, L.A., Dambrosia, J.M., Dickens, B.F., Jelliffe, L.L., Hansen, R.L. and Phillips, T.M. 2001. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann. Neurol. 49:597–606. Reichelt, K.L. and Liu, Y. 1997. Presentation at Defeat Autism Now! Meeting, San Diego, CA. Sept 19–21. Geier, D.A. and Geier, M.R. 2006a. A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotox. Res. 10:57–64. Nataf, R., Skorupka, C., Amet, L., Lam, A., Springbett, A. and Lathe, R. 2006. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol. Appl. Pharmacol. 214:99–108. Shanahan, M.R., Venturini, A.J., Daiss, J.L. and Friedman, A.E. 2000. Peptide diagnostic markers for human disorders. European Patent Application. Ep 0 969 015 A2. 05 Jan. Horvath, K., Papadimitriou, J.C., Rabsztyn, A., Drachenberg, C. and Tildon, J.T. 1999. Gastrointestinal abnormalities in children with autistic disorder. J. Pediatr. 135:559–563. Connolly, A.M., Chez, M., Streif, E.M., Keeling, R.M., Golumbek, P.T., Kwon, J.M., Riviello, J.J., Robinson, R.G., Neuman, R.J. and Deuel, R.M. 2006. Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol. Psychiatry. 59:354–363. Vojdani, A., O’Bryan, T., Green, J.A., Mccandless, J., Woeller, K.N., Vojdani, E., Nourian, A.A. and Cooper, E.L. 2004b. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr. Neurosci. 7:151–161. Vojdani, A., Bazargan, M., Vojdani, E., Samadi, J., Nourian, A.A., Eghbalieh, N. and Cooper, E.L. 2004a. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin. Diagn. Lab. Immunol. 11:515–524. Singh, V.K., Warren, R., Averett, R. and Ghaziuddin, M. 1997. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr. Neurol. 17:88–90. Singh, V.K., Warren, R.P., Odell, J.D., Warren, W.L. and Cole, P. 1993. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav. Immun. 7:97–103. Hollander, E., DelGiudice-Asch, G., Simon, L., Schmeidler, J., Cartwright, C., DeCaria, C.M., Kwon, J., Cunningham-Rundles, C., Chapman, F. and Zabriskie, J.B. 1999. B lymphocyte antigen D8/17 and repetitive behaviors in autism. Am. J. Psychiatry. 156:317–320. Warren, R.P., Burger, R.A., Odell, D., Torres, A.R. and Warren, W.L. 1994. Decreased plasma concentrations of the C4B complement protein in autism. Arch. Pediatr. Adolesc. Med. 148:180–183. Warren, R.P., Yonk, J., Burger, R.W., Odell, D. and Warren, W.L. 1995. DR-positive T-cells in autism: Association with decreased plasma levels of the complement C4B protein. Neuropsychobiology 31:53–57. Warren, R.P., Yonk, L.J., Burger, R.A., Cole, P., Odell, J.D., Warren, W.L., White, E. and Singh, V.K. 1990. Deficiency of suppressor-inducer (CD4+CD45RA+) T-cells in autism. Immunol. Invest. 19:245–251. Denney, D.R., Frei, B.W. and Gaffney, G.R. 1996. Lymphocyte subsets and interleukin-2 receptors in autistic children. J. Autism Dev. Disord. 26:87–97. Plioplys, A.V., Greaves, A., Kazemi, K. and Silverman, E. 1994. Lymphocyte function in autism and Rett syndrome. Neuropsychobiology. 29:12–16. Renzoni, E., Beltrami, V., Sestini, P., Pompella, A., Menchetti, G. and Zappella, M. 1995. Brief report: allergological evaluation of children with autism. J. Autism Dev. Disord. 25:327–333. Sweeten, T.L., Posey, D.J. and McDougle, C.J. 2003. High blood monocyte counts and neopterin levels in children with autistic disorder. Am. J. Psychiatry. 160:1691–1693. Singh, V.K. 1996. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J. Neuroimmunol. 66:143–145. Warren, R.P., Odell, J.D., Warren, W.L., Burger, R.A., Maciulis, A., Daniels, W.W. and Torres, A.R. 1997. Brief report: immunoglobulin A deficiency in a subset of autistic subjects. J. Autism Dev. Disord. 27:187–192. Jyonouchi, H., Sun, S. and Le, H. 2001. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J. Neuroimmunol. 120:170–179. Stubbs, E.G. and Crawford, M.L. 1977. Depressed lymphocyte responsiveness in autistic children. J. Autism Child. Schizophr. 7:49–55. Warren, R.P., Margaretten, N.C., Pace, N.C. and Foster, A. 1986. Immune abnormalities in patients with autism. J. Autism Dev. Disord. 16:189–197. Warren, R.P., Foster, A. and Margaretten, N.C. 1987. Reduced natural killer cell activity in autism. J. Am. Acad. Child Adolesc. Psychiatry 26:333–335. Singh, V.K., Warren, R.P., Odell, J.D. and Cole, P. 1991. Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children. Clin. Immunol. Immunopathol. 61:448–455. Curin, J.M., Terzic, J., Petkovic, Z.B., Zekan, L., Terzic, I.M. and Susnjara, I.M. 2003. Lower cortisol and higher ACTH levels in individuals with autism. J. Autism Dev. Disord. 33:443–448. Tordjman, S., Anderson, G.M., McBride, P.A., Hertzig, M.E., Snow, M.E., Hall, L.M., Thompson, S.M., Ferrari, P. and Cohen, D.J. 1997. Plasma beta-endorphin, adrenocorticotropin hormone, and cortisol in autism. J. Child Psychol. Psychiatry. 38:705–715. Tordjman, S., Anderson, G.M., Botbol, M., Brailly-Tabard, S., Perez-Diaz, F., Graignic, R., Carlier, M., Schmit, G., Rolland, A.C., Bonnot, O., Trabado, S., Roubertoux, P. and Bronsard, G. 2009. Pain reactivity and plasma β-endorphin in children and adolescents with autistic disorder. PLoS ONE 4(8):e5289, doi:10.1371/journal.pone.0005289. Messahel, S., Pheasant, A.E., Pall, H., Ahmed-Choudhury, J., Sungum-Paliwal, R.S. and Vostanis, P. 1998. Urinary levels of neopterin and biopterin in autism. Neurosci. Lett. 241:17–20. Perry, E.K., Lee, M.L., Martin-Ruiz, C.M., Court, J.A., Volsen, S.G., Merrit, J., Folly, E., Iversen, P.E., Bauman, M.L., Perry, R.H. and Wenk, G.L. 2001. Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. Am. J. Psychiatry. 158:1058–1066. Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K.J., Sekine, Y., Suzuki, K., Minabe, Y., Takei, N., Iyo, M. and Mori, N. 2006. Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog. Neuropsychopharmacol. Biol. Psychiatry. 30:1529–1531. Geier, D.A. and Geier, M.R. 2006b. A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders. Horm. Res. 66:182–188. Moreno, H., Borjas, L., Arrieta, A., Sáez, L., Prassad, A., Estévez, J. and Bonilla, E. 1992. [Clinical heterogeneity of the autistic syndrome: a study of 60 families]. Invest. Clin. 33:13–31. Kulman, G., Lissoni, P., Rovelli, F., Roselli, M.G., Brivio, F. and Sequeri, P. 2000. Evidence of pineal endocrine hypofunction in autistic children. Neuro Endocrinol. Lett. 21:31–34. Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I.C., Delorme, R., Chabane, N., Mouren-Simeoni, M.C., Fauchereau, F., Durand, C.M., Chevalier, F., Drouot, X., Collet, C., Launay, J.M., Leboyer, M., Gillberg, C. and Bourgeron, T. 2008. Abnormal melatonin synthesis in autism spectrum disorders. Mol. Psychiatry. 13:90–98. Tordjman, S., Anderson, G.M., Pichard, N., Charbuy, H. and Touitou, Y. 2005. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biol. Psychiatry. 57:134–138. Lee, M., Martin-Ruiz, C., Graham, A., Court, J., Jaros, E., Perry, R., Iversen, P., Bauman, M. and Perry, E. 2002. Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain. 125:1483–1495. Martin-Ruiz, C.M., Lee, M., Perry, R.H., Baumann, M., Court, J.A. and Perry, E.K. 2004. Molecular analysis of nicotinic receptor expression in autism. Brain Res. Mol. Brain Res. 123:81–90. Rolf, L.H., Haarmann, F.Y., Grotemeyer, K.H. and Kehrer, H. 1993. Serotonin and amino acid content in platelets of autistic children. Acta Psychiatr. Scand. 87:312–316. Chugani, D.C., Muzik, O., Behen, M., Rothermel, R., Janisse, J.J., Lee, J. and Chugani, H.T. 1999. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann. Neurol. 45:287–295. Leboyer, M., Philippe, A., Bouvard, M., Guilloud-Bataille, M., Bondoux, D., Tabuteau, F., Feingold, J., Mouren-Simeoni, M.C. and Launay, J.M. 1999. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. Biol. Psychiatry. 45:158–163. Martineau, J., Barthélémy, C., Jouve, J., Muh, J.P. and Lelord, G. 1992. Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: age-related changes and drug effects. Dev. Med. Child Neurol. 34:593–603. James, S.J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D.W. and Neubrander, J.A. 2004. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr. 80:1611–1617. Geier, D.A., Kern, J.K., Garver, C.R., Adams, J.B., Audhya, T., Nataf, R. and Geier, M.R. 2009. Biomarkers of environmental toxicity and susceptibility in autism. J. Neurol. Sci. 280:101–108. Aldred, S., Moore, K.M., Fitzgerald, M. and Waring, R.H. 2003. Plasma amino acid levels in children with autism and their families. J. Autism Dev. Disord. 33:93–97. Filipek, P.A., Juranek, J., Nguyen, M.T., Cummings, C. and Gargus, J.J. 2004. Relative carnitine deficiency in autism. J. Autism Dev. Disord. 34:615–623. Hoshino, Y., Kumashiro, H., Yashima, Y., Kaneko, M., Numata, Y., Oshima, N. and Watanabe, A. 1980. Plasma cyclic AMP level in psychiatric diseases of childhood. Folia Psychiatr. Neurol. Jpn. 34:9–16. Vancassel, S., Durand, G., Barthélémy, C., Lejeune, B., Martineau, J., Guilloteau, D., Andrès, C. and Chalon, S. 2001. Plasma fatty acid levels in autistic children. Prostaglandins Leukot. Essent. Fatty Acids 65:1–7.