Figures & data
Figure 1. Effects on OVA-specific antibody levels. Levels of (a) IgE, (b) IgG, and (c) IgG2a response in young female BN and Wistar rats in the period following oral exposure to OVA. OVA was delivered to BN rats (♦) and Wistar (▪) rats on days 1 and 14, and thereafter daily from day 15 to day 42. At the same time, control BN rats (▴) and Wistar rats (•) received the same volume of saline. Data are presented as mean log2 titer (± SD) of six rats per group. a For BN or b Wistar rats, OVA-exposed group significantly differs from the control at p < 0.05.
Figure 2. Effects on histamine release. Release in young female (a) BN and (b) Wistar rats after oral exposure to OVA or saline on days 1 and 14, and thereafter daily from day 15 to day 42. White bars represent controls and black bars the OVA-exposed groups. Levels of histamine in plasma were measured using ELISA. Mean values (ng/ml) with 95% CI (confidence intervals) for the different groups are shown. * Significantly differs from control at p < 0.05.
Figure 3. Effects on granulocyte levels. Numbers of (a) basophils, (b) eosinophils, and (c) neutrophils in the blood of young female BN and Wistar rats in the period after oral exposure to OVA or saline (on day 49). White bars represent controls and black bars OVA-exposed groups. Data are presented as mean (± SD) of six rats per group. * Significantly differs from control at p < 0.05.
Figure 4. Effects on blood pressure. Levels of change in pressure values on day 49 in young female (a) BN and (b) Wistar rats after oral challenge with OVA (▪) or in control rats after oral challenge with saline (♦). Data shown are means (± SD) of repeated blood pressure measures (in mm Hg) for individual rats for a period of 7 h. The broken lines indicate the upper and lower limits of the 95% confidence range of blood pressure values for the control rats. A drop in blood pressure was considered significant when the value dropped below the 95% confidence range.
Table 1. Histopathologic changes in BN and Wistar rats sensitized to OVA.