Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

Figures & data

Table 1. Effect of IFNγ on severity or frequency of respiratory symptoms.

Symptom	Pre-trial	Post-trial	p value
Cough	3.53 ± 0.52	2.73 ± 0.59	< 0.001
Dyspnea	3.80 ± 0.41	0.60 ± 0.63	< 0.001
Morning Dyspnea	3.60 ± 0.74	2.80 ± 0.68	< 0.001
Sputum production (%)	100	73.3	< 0.001
Hemoptysis (%)	86.66	6.67	< 0.001

Values shown are mean ± SD; n = 15.

Table 2. Effect of IFNγ on quality-of-life indices.

Parameter	Pre-trial	Post-trial	p value
St. George (symptoms)	87.43 ± 5.94	75.56 ± 9.91	0.001
St. George (activity)	72.58 ± 8.33	45.33 ± 4.89	< 0.001
St. George (impacts)	69.88 ± 8.64	37.98 ± 9.35	< 0.001
St. George (total)	73.62 ± 6.35	46.51 ± 5.71	< 0.001
CAT	35.06 ± 1.83	26.80 ± 2.90	< 0.001
Need for oxygen therapy	2.46 ± 0.83	1.46 ± 0.51	0.004
6-months hospitalization	3.50 ± 0.75	1.64 ± 0.49	0.001

CAT, COPD Assessment Test.

Values shown are mean ± SD; n = 15.

Table 3. Effect of IFNγ on spirometric parameters.

Parameter	Pre-trial	Post-trial	p value
FEV1 (%)	48.43 ± 14.27	55.32 ± 18.37	0.065
FVC (%)	53.85 ± 12.21	61.55 ± 13.35	0.092
FEV1/FVC (%)	92.28 ± 17.59	95.42 ± 18.55	0.433

FEV₁, Forced expiratory volume in the first second; FVC, forced vital capacity; FEF_25–75%, forced expiratory flow 25–75%.

Values shown are mean ± SD; n = 15.

Table 4. Effect of IFNγ on immunologic parameters.

Parameter	Pre-trial	Post-trial	p value
IL-2 (pg/ml)	37.19 ± 3.65	51.95 ± 5.82	< 0.001
IL-4 (pg/ml)	43.80 ± 13.65	23.95 ± 10.06	< 0.001
IL-6 (pg/ml)	1.88 ± 0.49	0.95 ± 0.25	< 0.001
IL-10 (pg/ml)	33.77 ± 22.23	22.23 ± 6.27	< 0.001
IFNγ (pg/ml)	10.03 ± 5.42	24.62 ± 8.05	< 0.001
CGRP (pg/ml)	49.67 ± 7.55	36.25 ± 5.57	< 0.001
MMP9 (ng/ml)	22.55 ± 14.56	6.36 ± 0.02	0.001
TNFα (pg/ml)	29.38 ± 3.94	15.94 ± 3.78	< 0.001
TGFβ (pg/ml)	41.36 ± 7.06	19.80 ± 3.69	< 0.001

IL, interleukin; IFN, interferon; CGRP, calcitonin gene related peptide; MMP, matrix metalloproteinase; TNF, tumor necrosis factor; TGF, transforming growth factor.

Values shown are mean ± SD; n = 15.

Table 5. Effect of IFNγ on oxidative stress markers.

Parameter	Pre-trial	Post-trial	p value
Catalase (U/ml)	26.45 ± 5.20	25.37 ± 2.99	0.180
SOD (U/ml)	1.48 ± 0.39	1.33 ± 0.38	0.100
Total glutathione (μg/ml)	3.90 ± 4.09	8.80 ± 9.00	0.005
Reduced glutathione (μg/ml)	9.04 ± 10.99	11.02 ± 10.56	0.061
MDA (nmole/ml)	21.73 ± 12.62	9.49 ± 3.89	0.001

SOD, superoxide dismutase; MDA, malonedialdehyde.

Values shown are mean ± SD; n = 15.