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Research Article

Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma

Berran YucesoyDivision of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA, ;CDC/National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA, Correspondence[email protected]

Michael L. KashonCDC/National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA,

Victor J. JohnsonBRT-Burleson Research Technologies, Morrisville, NC, USA,

Zana L. LummusDivision of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA,

Kara FluhartyCDC/National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA,

Denyse GautrinUniversité de Montréal, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada,

André CartierUniversité de Montréal, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada,

Louis-Philippe BouletUniversité Laval, Hôpital Laval, Sainte-Foy, Québec, Canada,

Joaquin SastreDepartment of Allergy, Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain,

Santiago QuirceDepartment of Allergy, Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain,

Susan M. TarloDepartment of Medicine, and ;Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada,

Maria-Jesus CruzHospitals Vall D’Hebron, Barcelona and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain, and

Xavier MunozHospitals Vall D’Hebron, Barcelona and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain, and

Michael I. LusterWest Virginia University, School of Public Health, Morgantown, WV, USA

David I. BernsteinDivision of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA,

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Figures & data

Table 1. Demographics of study groups.

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Table 2. Distribution of genotype frequencies between the groups.

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Table 3. Logistic regression model for significant variations: DA⁺ versus AW controls.

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Table 4. Significant and correlated SNPs with putative regulatory function (RegulomeDB Score 1–3).

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Supplemental material

Supplemental Material.pdf

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Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma

Table 1. Demographics of study groups.

Table 2. Distribution of genotype frequencies between the groups.

Table 3. Logistic regression model for significant variations: DA⁺ versus AW controls.

Table 4. Significant and correlated SNPs with putative regulatory function (RegulomeDB Score 1–3).

Supplemental Material.pdf

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Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma

Figures & data

Table 1. Demographics of study groups.

Table 2. Distribution of genotype frequencies between the groups.

Table 3. Logistic regression model for significant variations: DA+ versus AW controls.

Table 4. Significant and correlated SNPs with putative regulatory function (RegulomeDB Score 1–3).

Supplemental Material.pdf

Reprints and Corporate Permissions

Academic Permissions

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Table 3. Logistic regression model for significant variations: DA⁺ versus AW controls.