Abstract
The effect of diallylsuphide (DAS) was investigated on mercuric chloride (HgCl2)-induced renal damage in rats. Oral administration of DAS (200 mg/kg) effectively inhibited the levels of antioxidant enzymes as compared to HgCl2-treated group. Exposure to HgCl2 also resulted in an increase in the uric acid, creatinine and blood urea nitrogen levels. A significant decrease in the uric acid, creatinine and blood urea nitrogen was also observed in DAS-pre-treated HgCl2 group. The results suggest that DAS possesses significant potential as nephroprotective agent.
Acknowledgement
This research project was supported by “Research Center of the Center for Female Scientific and Medical Colleges’’, Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.