No effect of fibrin sealant on drain output or functional recovery following simultaneous bilateral total knee arthroplasty

Figures & data

Table 1. Demographic data. Values are median (range)

Age, years	65 (33–81)
Females	11
BMI, kg/m^2	28 (23–44)
LOS, days	3 (3–22)
Surgery time for BSTKA, min	80 (62–130)

Consort flow diagram of 24 bilateral total knee replacements randomized in the study (n = 48 total knee replacements).

Table 2. Swelling in 19 patients (circumference (cm), postoperative strength (Nm/kg), ROM (degrees), and pain (VAS))

Fibrin/Placebo	Fibrin	Placebo	p-value
Swelling
Preoperatively ^a	45 (6)	45 (5)	0.2
Day 1 ^a	46 (5)	46 (5)	0.8
Day 2 ^a	48 (5)	47 (6)	0.7
Day 3 ^a	48 (5)	48 (5)	0.5
Day 7 ^a	48 (5)	48 (5)	0.6
Day 21 ^a	46 (5)	46 (5)	0.7
Strength
Preoperatively	1.1 (0.4)	1. 1 (0.5)	0.5
Day 3	0.2 (0.2)	0.2 (0.3)	0.3
Day 7	0.3 (0.2)	0.3 (0.3)	0.5
Day 21	0.6 (0.3)	0.6 (0.5)	1.0
ROM
Preoperatively
Flexion ^a	117 (14)	119 (14)	0.2
Extension ^b	4.5 (0–8.5)	3.5 (1–11)	0.5
Day 3
Flexion ^a	85 (11)	81 (13)	0.07
Extension ^b	8 (5–11)	6 (4–10)	0.5
Day 7
Flexion ^a	88 (11)	86 (14)	0.3
Extension ^b	8.5 (4–12)	7.5 (3–11)	0.5
Day 21
Flexion ^a	98 (11)	94 (15)	0.2
Extension ^b	6 (3–9)	5 (3–8)	0.4
VAS
Preoperatively
Rest ^b	7 (0–10)	7 ( 0–12)	0.8
Flexion ^b	10 (0–32)	4 (0–11)	0.3
Day 1
Rest ^b	22 (8.5–58)	26 (12–51)	0.8
Flexion ^b	45 (22–71)	44 (29–67)	0.7
Day 2
Rest ^b	8 (0–19)	4.5 (0–20)	0.8
Flexion ^b	10.5 (0–35)	10 (0–35)	0.9
Day 3
Rest ^b	10 (2–24)	10 (3–14)	0.2
Flexion ^b	5 (0–13)	5 (0–18)	1.0
Day 7
Rest ^b	5 (0–11)	5 (1–10)	0.6
Flexion ^b	0 (0–20)	0 (0–9.5)	0.4
Day 21
Rest ^b	2 (0–6)	0 (0–9)	0.6
Flexion ^b	0 (0–15)	0 (0–12)	0.3

^a Mean (SD)

^b Median (IQ)