Rising incidence of Enterococcus species in microbiological specimens from orthopedic patients correlates to increased use of cefuroxime

Figures & data

Table 1. Time trends in species distribution in partients with positive tissue cultures

Period	1990–1993		1994–1997		1998–2001		2002–2005		2006–2009
Microorganism	No. of patients	Percent	No. of patients	Percent	No. of patients	Percent	No. of patients	Percent	No. of patients	Percent
Stapylococcus aureus	27	47	38	46	35	43	74	53.5	136	51.5
Coagulase-negative staphylococcus	15	26	26	32	28	34	51	37	78	29.5
Beta-hemolytic streptococcus	4	7	8	10	6	7.5	8	6	21	8
Non-hemolytic streptococcus	2	3.5	2	2.5	1	1	2	1.5	4	1.5
Enterococcus species	11	19	10	12	10	12	33	24	58	22
Corynebacterium species	5	9	9	11	13	16	9	6.5	23	85
E. coli	2	3.5	7	8.5	10	12	7	5	24	9
Enterobacter species	6	10.5	1	1	0	0	0	0	20	7.5
Other Enterobactericeae	10	17.5	14	17	9	11	41	30	48	18
Anaerobic bacteria	3	5	7	8.5	6	7.5	21	15	36	13.5
Candida species	0	0	1	1	1	1	0	0	2	1
Other types	8	14	7	8.5	8	10	16	11.5	45	17
Total	93		129		127		270		495

Table 2. Number of patients and incidence of isolation of enterococci from clinical specimens

Year	2002	2003	2004	2005	2006	2007	2008	2009	2010
Orthopedic department
No. of patients with enterococci in tissue samples	18	14	19	32	22	48	85	136	119
Incidence ^a of patients with enterococci in tissue samples	1.03	0.8	1.2	2.1	1.5	3.5	4.5	5.9	5.6
Total hospital
No. of patients with enterococci (all specimens)	906	1,053	1,245	1,420	1,506	1,690	1,973	2,273	2,020
Incidence ^a of patients with enterococci (all specimens)	4.5	5.4	6.3	7.3	7.9	9.1	9.2	10.0	9.9

^a No. of patients/10³ bed days.

Consumption of antibiotics as defined daily doses (DDD) at the Department of Orthopedic Surgery, Herlev University Hospital, 2002–2010.