Cirrhosis is a risk factor for total hip arthroplasty for avascular necrosis

Figures & data

Table 1. Prevalence of risk factors for AVN at the index date, with ICD-8 and ICD-10 codes

	ICD-8	ICD-10	Cirrhosis patients (%)	Reference individuals (%)
Conditions predisposing to AVN
Diabetes mellitus	249.xx, 250.xx	E10.x–E14.x	13	4
HIV	079.83	B20.x–B24.x	0.26	0.06
Myeloproliferative disease	20x.xx	C88.x, C90–96.x	0.71	0.33
Hemoglobinopathy	282.xx	D55.x– D59.x	0.36	0.05
Chronic renal failure	58x.xx	N18.x	1.2	0.37
Gout	274.0x	M10.x	2.1	0.49
Solid organ transplantation	Y95.xx	Z94.x	0.28	0.15
Indicator of smoking
Chronic obstructive lung disease	490.xx–492.xx	J43.x–J44.x	7.2	2.4
Indicator of corticosteroid treatment
Autoimmune hepatitis	573.02	K73.2, K75.4	0.90	0.02
Rheumatoid arthritis	712.0x–712.2x	M05.x	0.56	0.44
Connective tissue disease	734.xx	M3x.x	0.73	1.2

Table 2. Results of the main regression analysis and the supplementary regression analysis

	No. of cirrhosis patients (with AVN)	No. of reference individuals (with AVN)	Unadjusted HR ^a (95% CI)	Adjusted HR ^b (95% CI)
Main analysis	23,421 (45)	114,052 (44)	9.9 (5.8–17)	10 (5.8–17)
Supplementary analysis	4,977 (9)	21,851 (11)	13 (3.5–48)	12 (3.3–47)

a Unadjusted hazard ratio of THA for AVN in cirrhosis patients vs. reference individuals

b Adjusted hazard ratio of THA for AVN in cirrhosis patients vs. reference individuals, adjusted for other risk factors for AVN; see Table 1.