Inhibin-betaC subunit expression in normal and pathological human placental tissues

Figures & data

Table 1. Clinical details of the patients and newborns with preeclampsia, HELLP syndrome, IUGR, and the normal control group of well characterized group of patients [Mylonas et al. 2006a; 2006b; Schiessl et al. 2005; 2006]. Data represent mean ± standard deviation.

	Control	Preeclampsia	HELLP	IUGR
n	6	8	5	5
Week of gestation at delivery	38.20 ± 3.90	33.18 ± 0.83	33.80 ± 2.80	32.50 ± 2.80
Neonatal birth weight (g)	3435.00 ± 412.20	1409.00 ± 547.00	1796.20 ± 689.10	1246.60 ± 42.30
pH umbilical artery	7.27 ± 0.09	7.29 ± 0.06	7.33 ± 0.09	7.25 ± 0.08
Apgar score at 5 min	9.40 ± 0.90	9.36 ± 0.67	9.20 ± 0.84	9.00 ± 0.70
Apgar score at 10 min	10.00 ± 0.00	9.73 ± 0.47	9.80 ± 0.50	9.60 ± 0.50

Figure 1. Immunohistochemical staining reaction of inhibin-βC in placental syncytiotrophoblast cells. Syncytiotrophoblast cells demonstrated a positive cytoplasmatic staining intensity for inhibin-βC antibody in normal ( A; lens 20, top left panel), preeclamptic ( B; lens 40, top right panel), HELLP (C; lens 40, lower left panel), and IUGR (D; lens 40, lower right panel) placental tissue.

Figure 2. Immunohistochemical staining reaction of inhibin-βC in placental extravillous trophoblast cells. Extravillous trophoblast cells demonstrated a positive cytoplasmatic staining intensity for inhibin-βC antibody in normal (A; lens 20, upper left panel), preeclamptic (B; lens 20, upper right panel), HELLP (C; lens 20, lower left panel), and IUGR (D; lens 40, lower right panel) placental tissue.

Figure 3. Immunohistochemical evaluation of the inhibin-βC subunits in normal, preeclamptic, and HELLP placenta tissue. The immunoreactive score for inhibin-βC did not show any significant differences between normal, preeclamptic, HELLP, or IUGR placental tissue in syncytiotrophoblast cells and extravillous trophoblast. Data represent mean ± SEM. Significance was assumed at p < 0.05.