Figures & data
Figure 1. Steroidogenic response, ERK1/2 activation, and morphological changes of bonnet macaque CL after luteotrophic stimulus on day 1 of the menses. A and B) Scatter graphs (mean ± SEM) concentrations of serum P4 after LH and hCG administration. C) Scatter graph (mean ± SEM) concentrations of serum E2 levels after hCG administration. D) Mean ± SEM concentration of P4 after LH stimulus on day 1 of the menses in lutectomized animals. E) Western blots of PERK1/2, ERK1/2, PMKK3/6 and β-actin loading control for pooled samples of untreated and hCG treated CL. F) Haematoxylin and eosin stained regressing CL on day 1 of the menses before and after hCG treatment. The black arrow indicates pyknotic nuclei and the black dotted arrow indicates the cells with decreased cell volume in representative images (100x magnification). *: P < 0.05 when analyzed with paired t-test in comparison to vehicle treated control animals; P4: progesterone; PBS: phosphate buffered saline; rhLH: recombinant human luteinizing hormone; hCG: human chorionic gonadotropin; E2: estradiol; CL: corpus luteum; D1: day 1
