Outcome of microdissection testicular sperm extraction in azoospermic patients with Klinefelter syndrome and other sex-chromosomal anomalies

Figures & data

Table 1. Comparison of several parameters in 42 patients including patients with sex chromosomal anomalies.

	Overall (n = 42)	KFS (n = 35)	Others (n = 7)	P-value
Age (years)	34.4 ± 4.3	34.2 ± 4.4	35.6 ± 3.7	0.40
FSH (IU/l)	33.7 ± 14.6	36.3 ± 14.0	20.8 ± 10.4	0.0056
LH (IU/l)	14.5 ± 7.0	15.8 ± 6.7	8.2 ± 5.2	0.0066
T (ng/ml)	3.4 ± 1.9	3.2 ± 2.0	4.1 ± 1.5	0.22
Testicular volume (ml)	5.0 ± 3.4	4.0 ± 2.1	9.9 ± 4.6	0.0014
Type of chromosomal anomalies	–	47,XXY mosaic/ non-mosaic	46, X, r(Y) 46, X, add(X) (p22.3) 46, X, idic (Y) (q11.2) /del(Y) (q11.2) 48, XXY +mar, Y (q11.23) 46, X, idic(Y)(q11.2) 46, XY [26] / 45X [4] 47, XYY

FSH: follicle stimulating hormone; LH: luteinizing hormone; T: testosterone; KFS: Klinefelter syndrome

Table 2. Comparison of several parameters in 40 patients with successful and unsuccessful sperm retrieval.

	Successful (n = 17)	Unsuccessful (n = 23)	P-value
Age (years)	32.9 ± 4.1	35.5 ± 4.1	0.053
FSH (IU/l)	35.3 ± 19.1	32.7 ± 11.3	0.63
LH (IU/l)	14.9 ± 9.3	14.2 ± 5.1	0.79
T (ng/ml)	3.5 ± 2.2	3.3 ± 1.7	0.096
Testicular volume (ml)	5.9 ± 4.2	4.5 ± 2.7	0.22

FSH: follicle stimulating hormone; LH: luteinizing hormone; T: testosterone

Table 3. Comparison of SRR between KFS and other sex chromosome anomalies.

	Successful (n = 17)	Unsuccessful (n = 23)	P-value
Type of karyotype
KFS	14	19	0.67
Non-mosaic Mosaic	12 2	18 1
Others	3	4	–
46, X, r(Y)	0	1
46, X, add(X) (p22.3)	0	1
46, X, idic (Y) (q11.2) /del(Y) (q11.2)	1	0
48, XXY +mar, Y (q11.23)	0	1
46, X, idic(Y)(q11.2)	1	0
46, XY [26] / 45X [4]	0	1
47, XYY	1	0

SRR: sperm retrieval rate; KFS: Klinefelter syndrome

Table 4. Comparison of deletion of Yq between successful and unsuccessful sperm retrieva l.

	Successful (n = 17)	Unsuccessful (n = 23)	P-value
Deletion of Yq
No	16	20	0.62
Yes	1	3