Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology

Figures & data

Table 1. Aneuploidy frequency after assisted reproductive technologies in past studies.

Study	Number of Specimens	Rate of Aneuploidy	Reference
Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population	299	71.6	[Werner et al. 2012]
Aneuploidy rates in failed pregnancies following assisted reproductive technology	59	83	[Nayak, et al. 2011]
Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment	382	52.6	[Kim et al. 2010]
Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment	451	51	[Martinez et al. 2010]
Aneuploidy in abortuses following IVF and ICSI	355	50.1	[Kushnir and Frattarelli 2009]
Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF	11	36.4	[Verpoest et al. 2008]
Aneuploidy in the miscarriages of infertile women and the potential benefit of preimplantation genetic diagnosis	273	64.8	[Lathi et al. 2008]
Chromosomal abnormalities in miscarriages after different assisted reproduction procedures	277	63.2	[Bettio, et al. 2008]
Frequency of chromosomal abnormalities in spontaneous abortions from intracytoplasmic sperm injection compared with those from in vitro fertilization	80	64	[Ma et al. 2006]
Relationship between maternal age and aneuploidy in in vitro fertilization pregnancy loss	74	52	[Spandorfer et al. 2004]
Chromosome analysis of spontaneous abortions after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)	64	45.3	[Causio et al. 2002]
Chromosomal analysis of early fetal losses in relation to transvaginal ultrasonographic detection of fetal heart motion after infertility	52	69.2	[Schmidt-Sarosi et al. 1998]
Chromosomal analysis of pregnancy losses in patients undergoing assisted reproduction	18	50	[Shields et al. 1992]
Chromosome analysis of spontaneous abortions after IVF. A European survey	34	62	[Plachot 1989]
Karyotype analysis of blighted ova in pregnancies achieved by in vitro fertilization	13	38	[Roesler et al. 1989]

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Kushnir, V.A. and Frattarelli, J.L. (2009) Aneuploidy in abortuses following IVF and ICSI. J Assist Reprod Genet 26:93–97.

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Verpoest, W., Fauser, B.C., Papanikolaou, E., Staessen, C., Van Landuyt, L., Donoso, P., (2008) Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF. Hum Reprod 23:2369–2371.

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Lathi, R.B., Westphal, L.M. and Milki, A.A. (2008) Aneuploidy in the miscarriages of infertile women and the potential benefit of preimplanation genetic diagnosis. Fertil Steril 89:353–357.

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Bettio, D., Venci, A. and Levi Setti, P.E. (2008) Chromosomal abnormalities in miscarriages after different assisted reproduction procedures. Placenta 29 Suppl B: 126–128.

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Ma, S., Philipp, T., Zhao, Y., Stetten, G., Robinson, W.P. and Kalousek, D. (2006) Frequency of chromosomal abnormalities in spontaneous abortions derived from intracytoplasmic sperm injection compared with those from in vitro fertilization. Fertil Steril 85:236–239.

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Spandorfer, S.D., Davis, O.K., Barmat, L.I., Chung, P.H. and Rosenwaks, Z. (2004) Relationship between maternal age and aneuploidy in in vitro fertilization pregnancy loss. Fertil Steril 81:1265–1269.

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Schmidt-Sarosi, C., Schwartz, L.B., Lublin, J., Kaplan-Grazi, D., Sarosi, P. and Perle, M.A. (1998) Chromosomal analysis of early fetal losses in relation to transvaginal ultrasonographic detection of fetal heart motion after infertility. Fertil Steril 69:274–277.

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Shields, L.E., Serafini, P.C., Schenken, R.S. and Moore, C.M. (1992) Chromosomal analysis of pregnancy losses in patients undergoing assisted reproduction. J Assist Reprod Genet 9:57–60.

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Plachot, M. (1989) Chromosome analysis of spontaneous abortions after IVF. A European survey. Hum Reprod 4:425–429.

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Roesler, M., Wise, L. and Katayama, K.P. (1989) Karyotype analysis of blighted ova in pregnancies achieved by in vitro fertilization. Fertil Steril 51:1065–1066.

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