Figures & data: Effects of dalfampridine and its metabolites on cloned human potassium channels Kv 1.1, Kv 1.2, and Kv 1.4 expressed in human embryonic kidney cells

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Table 1. Characteristics of K_v 1.1, 1.2, and 1.4 potassium channels (adapted with permission from Gutman et al.Citation16).

Figure 1. Concentration–response curves of 4-aminopyridine for the potassium channels K_v 1.1 (A), K_v 1.2 (B), and K_v 1.4 (C). Values represent mean percent inhibition ± standard deviation; numbers in parentheses represent the number of replicates.

Figure 2. Concentration–response curves of 3-hydroxy-4-aminopyridine for the potassium channels K_v 1.1 (A), K_v 1.2 (B), and K_v 1.4 (C). Values represent mean percent inhibition ± standard deviation; numbers in parentheses represent the number of replicates.

Figure 3. Concentration–response curves of 3-hydroxy-4-aminopyridine sulfate for the potassium channels K_v 1.1 (A) and K_v 1.2 (B). Values represent mean percent inhibition ± standard deviation; numbers in parentheses represent the number of replicates.

Table 2. Concentrations of 4-aminopyridine and its two major metabolites that result in 50% inhibition of peak current of the recombinant potassium channels K_v 1.1, K_v 1.2, and K_v 1.4.

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Table 3. Effect of 4-aminopyridine and its two major metabolites on K_v 1.4 kinetics of inactivation. Positive values indicate acceleration of inactivation.

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Effects of dalfampridine and its metabolites on cloned human potassium channels K_v 1.1, K_v 1.2, and K_v 1.4 expressed in human embryonic kidney cells

Table 1. Characteristics of K_v 1.1, 1.2, and 1.4 potassium channels (adapted with permission from Gutman et al.Citation16).

Table 2. Concentrations of 4-aminopyridine and its two major metabolites that result in 50% inhibition of peak current of the recombinant potassium channels K_v 1.1, K_v 1.2, and K_v 1.4.

Table 3. Effect of 4-aminopyridine and its two major metabolites on K_v 1.4 kinetics of inactivation. Positive values indicate acceleration of inactivation.

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Effects of dalfampridine and its metabolites on cloned human potassium channels Kv 1.1, Kv 1.2, and Kv 1.4 expressed in human embryonic kidney cells

Figures & data

Table 1. Characteristics of Kv 1.1, 1.2, and 1.4 potassium channels (adapted with permission from Gutman et al.Citation16).

Table 2. Concentrations of 4-aminopyridine and its two major metabolites that result in 50% inhibition of peak current of the recombinant potassium channels Kv 1.1, Kv 1.2, and Kv 1.4.

Table 3. Effect of 4-aminopyridine and its two major metabolites on Kv 1.4 kinetics of inactivation. Positive values indicate acceleration of inactivation.

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Effects of dalfampridine and its metabolites on cloned human potassium channels K_v 1.1, K_v 1.2, and K_v 1.4 expressed in human embryonic kidney cells

Table 1. Characteristics of K_v 1.1, 1.2, and 1.4 potassium channels (adapted with permission from Gutman et al.Citation16).

Table 2. Concentrations of 4-aminopyridine and its two major metabolites that result in 50% inhibition of peak current of the recombinant potassium channels K_v 1.1, K_v 1.2, and K_v 1.4.

Table 3. Effect of 4-aminopyridine and its two major metabolites on K_v 1.4 kinetics of inactivation. Positive values indicate acceleration of inactivation.