ALS Untangled No. 20: The Deanna Protocol

Figures & data

Table I. The original Deanna Protocol, as provided by Tedone. The purpose of each supplement described in the table is according to Tedone and is not based on the evidence provided in this paper. The protocol below has recently been revised to now include additional AKG supplementation hourly while awake.

Supplement	Dosage	Hypothesized purpose
Arginine alpha ketoglutarate (AAKG)*	Up to 18 g daily	Delivers energy to nerves
Nicotinamide adenine dinucleotide (NADH)*	20 mg 2 times daily	Stops nerve cell death
GABA*	250 mg 2 times daily	Inhibitory neurotransmitter
Glutathione*	350 mg 3 times daily	Free radical scavenger in the nervous system
Ibedenone*	180 mg daily	Facilitates energy to nerves
Ubiquinol (CoQ100)*	200 mg daily	Helps energy cycle in mitochondria
B complex	Standard dosage from bottle	General nerve health
Bee Propolis	200 mg daily	Antioxidant for nervous system
CoQ10	Standard dosage from bottle	Helps energy cycle in mitochondria
5-hydroxy tryptophan	50 mg nightly	Serotonin and melatonin precursors
Creatine	1758 mg daily	General muscle health and recovery
Cysteplus	500 mg daily	Counteracts glutamate hyperactivity
Ginkgo Biloba	120 mg daily	Protects against glutamate excitotoxicity
Glutathione	3000 mg IV weekly	Free radical scavenger
Glycine	500 mg twice daily	Balance neurotransmitters
Magnesium	400 mg daily	Calms nerves
Methyl folic acid (5-MTHF)	1 mg twice daily	Needed with B12 for metabolism
Neurochondria	1 pill daily, one dose contains:
	1500 mcg of Vitamin B12;
	300 mcg of Folate;
	250 mg of Benfotiamine;
	150 mg of CoQ10;
	120 mg of R-Lipoic acid;
	150 mg of Glutathione;
	300 mg of Acetyl-L-Carnitine;
	150 mg of Phosphatidylserine
	Nerve metabolism
Opti Zinc	30 mg daily	Increases bioavailability of zinc, stabilized calcium channels
Phosphatidylcholine	840 mg twice daily	Needed for cellular maintenance
Taurine	500 mg twice daily	Protects against glutamine overstimulation
Theanine	200 mg daily	Enhances and increases GABA
Vitamin D3	5000 IU daily	Most active form of D3
Vitamin D	10,000 IU daily	Helps with balance

*These supplements are indicated by Tedone as the most important supplements in the protocol.