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Report

Case report of concurrent Fabry disease and amyotrophic lateral sclerosis supports a common pathway of pathogenesis

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Pages 614-616 | Received 21 Dec 2015, Accepted 28 Feb 2016, Published online: 20 Apr 2016

Figures & data

Figure 1. MRI brain scan from the patient with concurrent Fabry’s disease and amyotrophic lateral sclerosis. (A and B) T2 weighted transverse MRI scan showing symmetrical white matter change; (C) Sagittal FLAIR MRI scan showing white matter changes in the cerebral hemispheres; and (D) T2 weighted transverse MRI showing white matter changes in the brainstem.

Figure 1. MRI brain scan from the patient with concurrent Fabry’s disease and amyotrophic lateral sclerosis. (A and B) T2 weighted transverse MRI scan showing symmetrical white matter change; (C) Sagittal FLAIR MRI scan showing white matter changes in the cerebral hemispheres; and (D) T2 weighted transverse MRI showing white matter changes in the brainstem.

Figure 2. Autophagy is dysregulated in mouse models of both Fabry’s disease and SOD1-G93A amyotrophic lateral sclerosis.

Figure 2. Autophagy is dysregulated in mouse models of both Fabry’s disease and SOD1-G93A amyotrophic lateral sclerosis.