Soluplus-coated colloidal silica nanomatrix system for enhanced supersaturation and oral absorption of poorly water-soluble drugs

Figures & data

Figure 1. SEM of Aerosil 200 (a) and Soluplus-coated colloidal silica nanomatrix (SCCSN) containing atorvastatin calcium (b), dutasteride (c), and sorafenib tosylate (d).

Figure 2. Powder X-ray diffraction patterns (a) and DSC thermograms (b) of raw materials and SCCSN.

Figure 3. Kinetic solubility of raw material, physical mixture, and SCCSN for atorvastatin calcium (a), dutasteride (b), and sorafenib tosylate (c) (data represented as mean ± SD, n = 3).

Figure 4. Plasma concentration–time profile of dutasteride in rats (data represented as mean ± SD, n = 4).

Table I. Pharmacokinetic parameters of dutasteride in rats (data represented as mean ± SD, n = 4).

Formulations	Pharmacokinetic parameters
	AUC0→24h (ng·h^− 1∙mL^− 1)	Cmax (ng/mL)	Tmax (h)
Soluplus-coated colloidal silica nanomatrix	2858.2 ± 587.5	180.4 ± 22.4	4.0 ± 2.2
Physical mixture	605.5 ± 125.3	54.5 ± 13.7	4.8 ± 1.7