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Research Article

An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis

, , , , , , , & show all
Pages 344-355 | Received 28 May 2013, Accepted 13 Jun 2013, Published online: 30 Jul 2013

Figures & data

Figure 1. The upper row – a photograph of P3HB filling material (I), porous 3D implants: life-size (II), and × 10 magnified (III); the lower row – SEM images of P3HB porous implant.

Figure 1. The upper row – a photograph of P3HB filling material (I), porous 3D implants: life-size (II), and × 10 magnified (III); the lower row – SEM images of P3HB porous implant.

Table I. Characterization of P3HB-based 3D implants.

Figure 2. Cross section samples of the bones at the defect site; implants: I – P3HB, II – P3HB/HA composite (HA 20 wt%), III – Bio-Oss® (arrows).

Figure 2. Cross section samples of the bones at the defect site; implants: I – P3HB, II – P3HB/HA composite (HA 20 wt%), III – Bio-Oss® (arrows).

Figure 3. Radiological data on the regeneration dynamics of the model defects of bone tissue in experiments with different implants.

Figure 3. Radiological data on the regeneration dynamics of the model defects of bone tissue in experiments with different implants.

Figure 4. New tissue at the implantation site: I – P3HB, II – P3HB/HA, III – Bio-Oss – at different time points after surgery. Magnification: × 100 hematoxylin–eosin.

Figure 4. New tissue at the implantation site: I – P3HB, II – P3HB/HA, III – Bio-Oss – at different time points after surgery. Magnification: × 100 hematoxylin–eosin.

Figure 5. Radiological data on the regeneration dynamics of the defects of bone tissue infected with Staphylococcus aureus in experiments with different implants: I – bone allograft; II – powdered P3HB; III – powdered P3HB/tienam.

Figure 5. Radiological data on the regeneration dynamics of the defects of bone tissue infected with Staphylococcus aureus in experiments with different implants: I – bone allograft; II – powdered P3HB; III – powdered P3HB/tienam.

Table II. Results of microbiological investigation of the samples.

Figure 6. New tissue at the site of implantation of I – powdered bone allograft, II – P3HB, and III – P3HB/tienam at different time points after surgery. Magnification: × 100 hematoxylin–eosin.

Figure 6. New tissue at the site of implantation of I – powdered bone allograft, II – P3HB, and III – P3HB/tienam at different time points after surgery. Magnification: × 100 hematoxylin–eosin.

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