Study on clinical application of nano-hydroxyapatite bone in bone defect repair

Figures & data

Figure 1. (A) Nano-HA artificial bone. (B) Nano-HA artificial bone under scanning electron microscope (SEM × 200).

Table I. Detecting report of the Nano-HA material.

Column	Demands in technology	Detection results	Conclusion
Granularity	1 ˜ 100 nm	89 nm	Acceptable
Density	< 2.0 g cm^− 3	1.1 g cm^− 3	Acceptable
Pore ratio	> 90%	93%	Acceptable
Ca/P ratio	1.62 ± 0.05	1.62	Acceptable
HA Crystal ratio	> 98%	98.5%	Acceptable
Heavy metals	As < 9 Cd < 5 Hg < 5 Pb < 30 Sum < 50	8 1 4 5 18	Acceptable
PH	6.5–7.5	6.8	Acceptable
Residual quantity of epoxy ethane	≤ 10 ug/g	2 ug/g	Acceptable
Ames teratogenesis experiments	Negative	Negative	Acceptable

Figure 2. (A) Exposing fracture of tibial plateau and bone defect. (B) Implanting Nano-HA artificial bone.

Figure 3. (A) Preoperative: fracture of left tibial plateau. (B) 3 months postoperatively: The delimitation between new bone tissue and normal bone tissue were clear. (C) 26 months postoperatively: most of the material was degraded and new bone tissue was formatted.