Figures & data
Table I. Sequence of primers.
Figure 2. Scanning electron micrographs of pH and thermo-responsive silica nanocomposites (NIPMACIL@MSNs).
![Figure 2. Scanning electron micrographs of pH and thermo-responsive silica nanocomposites (NIPMACIL@MSNs).](/cms/asset/57a97cb3-5c2b-4115-8efe-e4b55571258d/ianb_a_975235_f0002_b.gif)
Figure 5. Cell growth inhibition rates by different concentrations of drug-free NIPMACIL@MSN nanocomposites, MTX and MTX@NIPMACIL@MSN nanocomposites.
![Figure 5. Cell growth inhibition rates by different concentrations of drug-free NIPMACIL@MSN nanocomposites, MTX and MTX@NIPMACIL@MSN nanocomposites.](/cms/asset/64680ab0-32df-4662-b492-174e24e6863c/ianb_a_975235_f0005_oc.jpg)
Figure 6. qRT-PCR analysis of Bcl-2, synergistic effect of MTX and MTX@NIPMACIL@MSNs, in different concentrations on Bcl-2 expression. Bcl-2 mRNA level was more abundantly down-regulated in cultured cells, in 800 μg/Ml of MTX@NIPMACIL@MSNs (4 mg/ml Silica nano composite and 0.8 mg/ml Methotrexate) concentration shows more Bcl-2 mRNA level down-regulation.
![Figure 6. qRT-PCR analysis of Bcl-2, synergistic effect of MTX and MTX@NIPMACIL@MSNs, in different concentrations on Bcl-2 expression. Bcl-2 mRNA level was more abundantly down-regulated in cultured cells, in 800 μg/Ml of MTX@NIPMACIL@MSNs (4 mg/ml Silica nano composite and 0.8 mg/ml Methotrexate) concentration shows more Bcl-2 mRNA level down-regulation.](/cms/asset/73b5112e-570b-4138-946a-c16c23917af4/ianb_a_975235_f0006_b.gif)
Figure 7. qRT-PCR analysis of Bax, synergistic effect of MTX and MTX@NIPMACIL@MSNs, in different concentrations on Bax expression. Bax mRNA level was more abundantly up regulated in cultured cells, in 800 μg/Ml of MTX@NIPMACIL@MSNs (4 mg/ml Silica nano composite and 0.8 mg/ml Methotrexate) concentration shows more Bax mRNA level up-regulation.
![Figure 7. qRT-PCR analysis of Bax, synergistic effect of MTX and MTX@NIPMACIL@MSNs, in different concentrations on Bax expression. Bax mRNA level was more abundantly up regulated in cultured cells, in 800 μg/Ml of MTX@NIPMACIL@MSNs (4 mg/ml Silica nano composite and 0.8 mg/ml Methotrexate) concentration shows more Bax mRNA level up-regulation.](/cms/asset/b82fab79-2829-42f2-9339-6a16804231d4/ianb_a_975235_f0007_b.gif)