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ORIGINAL ARTICLE

Effects of chitosan nanoparticle-mediated BRAF siRNA interference on invasion and metastasis of gastric cancer cells

Pages 1232-1235 | Received 30 Nov 2014, Accepted 08 Feb 2015, Published online: 20 Mar 2015

Figures & data

Figure 1. Morphology of chitosan-encapsulated BRAF-siRNA nanoparticles under atomic force microscope (× 40000).

Figure 1. Morphology of chitosan-encapsulated BRAF-siRNA nanoparticles under atomic force microscope (× 40000).

Figure 2. Chitosan-encapsulated BRAF siRNA significantly downregulated the level of BRAF mRNA (#P < 0.001).

Figure 2. Chitosan-encapsulated BRAF siRNA significantly downregulated the level of BRAF mRNA (#P < 0.001).

Figure 3. Chitosan-encapsulated BRAF siRNA efficiently decreased the expression level of BRAF protein.

Figure 3. Chitosan-encapsulated BRAF siRNA efficiently decreased the expression level of BRAF protein.

Figure 4. Transwell assay showing significantly decreased invasion of BGC823 cells transfected with BRAF siRNA (#P < 0.001).

Figure 4. Transwell assay showing significantly decreased invasion of BGC823 cells transfected with BRAF siRNA (#P < 0.001).

Figure 5. Transwell assay showing significantly decreased invasion of BGC823 cells transfected with BRAF siRNA. The cells that migrated through the Matrigel were stained using crystal violet (Original magnification: × 200).

Figure 5. Transwell assay showing significantly decreased invasion of BGC823 cells transfected with BRAF siRNA. The cells that migrated through the Matrigel were stained using crystal violet (Original magnification: × 200).

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