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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 44, 2016 - Issue 5
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Review

Mesenchymal stem cell-based gene therapy: A promising therapeutic strategy

Mozhdeh MohammadianAmol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
,
Elham AbasiDepartment of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
&
Abolfazl AkbarzadehDepartment of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence[email protected]
Pages 1206-1211 | Received 01 Feb 2015, Accepted 05 Mar 2015, Published online: 06 Jul 2015

Figures & data

Figure 1. Benefits of MSC therapy. The cellular characteristics of MSCs are essential for their therapeutic uses.
Figure 1. Benefits of MSC therapy. The cellular characteristics of MSCs are essential for their therapeutic uses.
Figure 2. Stem cells can be manipulated to express the enzymes that metabolize non-toxic prodrugs locally, therefore allowing production of the active form of the drug or the expression of cytokines that perform directly on the tumor or activate immune cells, which, in order, attack the tumor.
Figure 2. Stem cells can be manipulated to express the enzymes that metabolize non-toxic prodrugs locally, therefore allowing production of the active form of the drug or the expression of cytokines that perform directly on the tumor or activate immune cells, which, in order, attack the tumor.
Figure 3. Immunoregulatory effects of MSCs on immune cells. CTL, cytotoxic T cells; HO, heme oxygenase; iDCs, immature dendritic cells; INOS, inducible nitric oxide synthase; mDCs, mature dendritic cells; NK cells, natural killer cells; PG, prostaglandin; Treg, regulatory T cells.
Figure 3. Immunoregulatory effects of MSCs on immune cells. CTL, cytotoxic T cells; HO, heme oxygenase; iDCs, immature dendritic cells; INOS, inducible nitric oxide synthase; mDCs, mature dendritic cells; NK cells, natural killer cells; PG, prostaglandin; Treg, regulatory T cells.

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