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Research Article

Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots

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Pages 1774-1782 | Received 28 Jul 2015, Accepted 29 Sep 2015, Published online: 27 Oct 2015

Figures & data

Figure 1. Shcematic representation of doxorubicin beairng FA-CHI conjugated QDs and their function.

Figure 1. Shcematic representation of doxorubicin beairng FA-CHI conjugated QDs and their function.

Figure 2. Synthesis scheme of DOX/FA/CHI-QDs.

Figure 2. Synthesis scheme of DOX/FA/CHI-QDs.

Figure 3. (A) UV spectroscopy of prepared QDs. FTIR spectroscopy of (B) NHS activated FA, (C) prepared QDs, and (D) DOX/FA-CS-QDs.

Figure 3. (A) UV spectroscopy of prepared QDs. FTIR spectroscopy of (B) NHS activated FA, (C) prepared QDs, and (D) DOX/FA-CS-QDs.

Figure 4. Motic microscopic image of synthesized QDs at different magnifications.

Figure 4. Motic microscopic image of synthesized QDs at different magnifications.

Figure 5. Percent cumulative DOX release from the QDs formulations at pH 5.0 and 7.4. Values represent mean ± S.D. (n=3).

Figure 5. Percent cumulative DOX release from the QDs formulations at pH 5.0 and 7.4. Values represent mean ± S.D. (n=3).

Figure 6. Percent cell viability of DOX, DOX-QDs and DOX/FA-CHI-QDs final formulations.

Figure 6. Percent cell viability of DOX, DOX-QDs and DOX/FA-CHI-QDs final formulations.

Figure 7. The fluorescence images of the treated MCF-7 cell lines with DOX, DOX-QDs and DOX/FA-CHI-QDs formulations.

Figure 7. The fluorescence images of the treated MCF-7 cell lines with DOX, DOX-QDs and DOX/FA-CHI-QDs formulations.

Figure 8. Tissue-organ biodistribution study for DOX, DOX-QDs and DOX/FA-CHI-QDs different formulation.

Figure 8. Tissue-organ biodistribution study for DOX, DOX-QDs and DOX/FA-CHI-QDs different formulation.

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