Different expression of miR-29b and VEGFA in glioma

Figures & data

Figure 1. The relation between miR-29b and VEGFA.

Figure 2. Expression of circulating miR-29b and VEGFA in glioma cases and healthy controls. (A) Expression of circulating miR-29b in stages I and II, stages III and IV glioma cases and healthy controls. (B) Expression of circulating VEGFA in stages I and II, stages III and IV glioma cases and healthy controls.

Table I. Correlation of serum miR-29b and VEGFA expression with clinicopathological features of glioma.

Clinicopathological features	N	miR-29b		P	VEGFA		P
		High	Low		High	Low
Gender	240	123	117	0.535			0.528
Female	131	67	64		63	68
Male	109	56	53		52	57
Age (years)		112	128		130	110
<50	103	49	54	0.455	52	51	0.194
≥50	137	63	74		78	59
WHO grade		115	125		119	121
WHO I–II	156	90	66	<0.001	65	91	<0.001
WHO III–IV	84	25	59		54	30
KPS		124	116		116	124
≥80	126	71	55	0.081	50	76	0.004
<80	114	53	61		66	48
Tumor size
≥5 cm	79	30	49	<0.001	50	29	0.195
<5 cm	161	112	49		91	70
Extent of resection		125	115		130	110
Total resection	189	99	90	0.480	101	88	0.392
Partial resection	51	26	25		29	22
Adjuvant treatment		124	116		123	117
Radiotherapy	108	64	44	0.946	57	51	0.550
Chemotherapy	33	20	13		19	14
Radiotherapy combined with Chemotherapy	99	59	40		47	52

The P value in bold was statistically significant.

Figure 3. The association between circulating miR-29b and VEGFA in glioma cases.

Figure 4. ROC curves of circulating miR-29b and VEGFA for the diagnosis of glioma.

Figure 5. The circulating miR-29b and VEGFA level of pre- and post-operation of the glioma patients.

Table II. Clinicopathological features and serum biomarkers as risk factors of glioma.

Parameter	Risk ratio	95% Confidence interval	P
Gender	1.539	0.664–2.274	0.629
Age	2.236	0.831–3.925	0.547
Tobacco smoking	2.861	1.323–4.894	0.026
Alcohol drinking	2.425	0.863–4.381	0.476
Radiation contact	0.653	0.342–2.763	0.341
Glioma history	0.912	0.452–2.183	0.362
miR-29b expression	0.492	0.238–0.882	0.001
VEGFA expression	2.826	1.93–4.545	<0.001

The P value in bold was statistically significant.