Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome

Figures & data

Table 1. AWR scores at different pressures (point, x ± s).

		Pressure (mmHg)
Group	Number	20	40	60	80
NC-2W	10	0.85 ± 0.19	1.41 ± 0.11	2.67 ± 0.18	3.74 ± 0.20
PI-2W	10	0.97 ± 0.22	2.79 ± 0.16*	3.64 ± 0.22*	3.72 ± 0.14
NC-8W	10	0.75 ± 0.14	1.39 ± 0.15	2.57 ± 0.15	3.53 ± 0.32
PI-8W	10	0.86 ± 0.21	2.39 ± 0.22#	3.12 ± 0.33#	3.72 ± 0.13
PI-B	10	0.92 ± 0.23	1.59 ± 0.20△	2.74 ± 0.25△	3.71 ± 0.16

Compared with NC-2W group,

*P < 0.05; compared with NC-8W group,

#P < 0.05; compared with PI-8W group,

△P < 0.05.

Figure 1. Locations of NLRP3 (A), ASC (B) and caspase-1 (C) in the mucous layer of ileal tissues; nuclei (blue), cytoplasm (green).

Figure 2. Expressions of NLRP3 inflammasome and related proteins. (A) Comparisons between PI-2W and NC-2W groups; (B) comparisons between PI-8W and NC-8W groups; (C) comparisons between PI-2W and PI-8W groups; (D) comparisons between PI-8W and PI-B groups. *P < 0.05. n = 10, each experiment was performed in triplicate, and the mean was used.