Pharmacodynamics study of zedoary turmeric oil chitosan microspheres administered via arterial embolization

Figures & data

Figure 1. The schema chart of the animal model (TACE).

Table I. Grouping and dosage (n = 16).

Formulation	Dosage
Normal saline	0.2 ml/kg
ZTO injection (0.1 g/10 ml)	7.5 mg/kg
ZTO microspheres	3.75 mg/kg
ZTO microspheres	7.5 mg/kg
ZTO microspheres	15 mg/kg

Figure 2. Scanning electron microscope photograph of ZTO-loaded chitosan microspheres: ×3000.

Figure 3. Changes of tumor volume in rats transplanted with hepatocellular carcinoma cells line walker-256 on seventh day (n = 8) *p < 0.05 the tumor volume before and after treatment.

Table II. The effect of ZTO-loaded chitosan microspheres and ZTO injection on rats of walker-256 cells (n = 8).

	TV (mm^3)
Formulation	D1	D7	Growth rate
Normal saline	0.081 ± 0.018	1.232 ± 0.26	15.21 ± 4.32
ZTO injection (7.5 mg/kg)	0.079 ± 0.014	0.753 ± 0.13	9.53 ± 2.13
ZTO microspheres (3.75 mg/kg)	0.076 ± 0.021	0.621 ± 0.14	8.17 ± 1.43^a
ZTO microspheres (7.5 mg/kg)	0.083 ± 0.017	0.575 ± 0.11	6.93 ± 1.01^a^b
ZTO microspheres (15 mg/kg)	0.072 ± 0.012	0.342 ± 0.09	4.75 ± 0.67^a^b

TV, tumor volume.

^ap < 0.05, compared with saline group.

^bp < 0.05, compared with ZTO injection group.

Figure 4. The survival time of the rats transplanted with hepatocellular carcinoma cells line walker-256 on seventh day after arterial infusion (n = 8).

Figure 5. Histopathological studies of liver. (A), control group; (B) ZTO-loaded chitosan microspheres.