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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 45, 2017 - Issue 2
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Original Articles

Enhanced brain targeting efficacy of Olanzapine through solid lipid nanoparticles

Jawahar NatarajanDepartment of Pharmaceutics, JSS College of Pharmacy, Udhagamandalam, JSS University, Mysore, India; Correspondence[email protected]
,
Mahendran BaskaranDepartment of Pharmaceutics, JSS College of Pharmacy, Udhagamandalam, JSS University, Mysore, India;
,
Lireni C. HumtsoeDepartment of Pharmaceutics, JSS College of Pharmacy, Udhagamandalam, JSS University, Mysore, India;
,
R. VadivelanDepartment of Pharmacology, JSS College of Pharmacy, Udhagamandalam, JSS University, Mysore, India
&
A. JustinDepartment of Pharmacology, JSS College of Pharmacy, Udhagamandalam, JSS University, Mysore, India
Pages 364-371 | Received 04 Oct 2015, Accepted 26 Feb 2016, Published online: 22 Mar 2016

Figures & data

Table 1. particle size, zeta potential, and entrapment efficiency.

Figure 1. Differential scanning calorimeter curves of OLZ and OLZ-SLN formulations. OLZ: Olanzapine; TP: glyceryl tripalmitate; GMS: glyceryl monostearate; SLNs: solid lipid nanoparticles.

Figure 1. Differential scanning calorimeter curves of OLZ and OLZ-SLN formulations. OLZ: Olanzapine; TP: glyceryl tripalmitate; GMS: glyceryl monostearate; SLNs: solid lipid nanoparticles.

Figure 2. SEM image of SLN.

Figure 2. SEM image of SLN.

Figure 3. Comparative in vitro release profile in phosphate buffer saline pH 7.4.

Figure 3. Comparative in vitro release profile in phosphate buffer saline pH 7.4.

Figure 4. Higuchi’s plot for TP-SLN.

Figure 4. Higuchi’s plot for TP-SLN.

Figure 5. Higuchi’s plot for GMS-SLN.

Figure 5. Higuchi’s plot for GMS-SLN.

Table 2. Regression value for various kinetic models.

Figure 6. Korsmeyer–Peppa’s plot for TP-SLN.

Figure 6. Korsmeyer–Peppa’s plot for TP-SLN.

Figure 7. Korsmeyer–Peppa’s plot for GMS-SLN.

Figure 7. Korsmeyer–Peppa’s plot for GMS-SLN.

Table 3. Pharmacokinetic parameters for OLZ in the plasma after i.v. administration.

Figure 8. Concentration–time curve of TP-SLN and OLZ-suspension.

Figure 8. Concentration–time curve of TP-SLN and OLZ-suspension.

Figure 9. The concentration–time curve of TP-SLN and OLZ-Suspension in the brain.

Figure 9. The concentration–time curve of TP-SLN and OLZ-Suspension in the brain.

Table 4. Pharmacokinetic parameters for formulation and pure drug in brain.

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Related Research Data

Fabrication of Niclosamide loaded solid lipid nanoparticles: in vitro characterization and comparative in vivo evaluation
Source: (:unav)
The Effect of Minor Doses of Olanzapine-Solid Lipid Nanoparticles on an Animal Model of Schizophrenia (Neurochemical and Behavioral Study) and the Side Effect
Source: Bentham Science Publishers Ltd.

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