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Original Article

Therapy persistence and adherence in patients with chronic obstructive pulmonary disease: multiple versus single long-acting maintenance inhalers

, , , , , , & show all
Pages 486-496 | Accepted 31 May 2011, Published online: 16 Jun 2011

Figures & data

Figure 1.  Sample selection flowchart. *Patients with COPD who had at least two occasions of filling two or more long-acting bronchodilator inhalers concomitantly or at least one long-acting bronchodilator inhaler and a separate ICS inhaler concomitantly for at least 7 consecutive days. Patients who had no record of filling more than one long-acting bronchodilator inhaler concomitantly or a long-acting bronchodilator and a separate ICS inhaler concomitantly at any time within a period of at least 18 months.

Figure 1.  Sample selection flowchart. *Patients with COPD who had at least two occasions of filling two or more long-acting bronchodilator inhalers concomitantly or at least one long-acting bronchodilator inhaler and a separate ICS inhaler concomitantly for at least 7 consecutive days. †Patients who had no record of filling more than one long-acting bronchodilator inhaler concomitantly or a long-acting bronchodilator and a separate ICS inhaler concomitantly at any time within a period of at least 18 months.

Table 1.  Matched patient baseline characteristics.

Table 2.  Prevalence of comorbidities in the single- and multiple-inhaler users during the baseline period, n (%).

Figure 2.  Treatment persistence (discontinuation rates) of single- and multiple-inhaler cohorts among (a) all, (b) well-controlled, and (c) poorly-controlled patients.

Figure 2.  Treatment persistence (discontinuation rates) of single- and multiple-inhaler cohorts among (a) all, (b) well-controlled, and (c) poorly-controlled patients.

Table 3.  Comparisons of treatment discontinuation rates between single- and multiple-inhaler users during the 12-month study period.

Figure 3.  Adherence of single- and multiple-inhaler users among (a) all, (b) well-controlled, and (c) poorly controlled patients.

Figure 3.  Adherence of single- and multiple-inhaler users among (a) all, (b) well-controlled, and (c) poorly controlled patients.

Table 4.  Adherence (PDC) comparison between single- and multiple-inhaler users during the 12-month study period.

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