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Original Article

Cost-effectiveness analysis of palivizumab among pre-term infant populations covered by Medicaid in the United States

, , &
Pages 997-1018 | Accepted 02 Mar 2012, Published online: 21 Mar 2012

Figures & data

Figure 1.  Structure of simple decision tree model. ICU = intensive care unit; RSV = respiratory syncytial virus.

Figure 1.  Structure of simple decision tree model. ICU = intensive care unit; RSV = respiratory syncytial virus.

Table 1.  Probabilities used in the model by palivizumab prophylaxis and no prophylaxis.

Table 2.  Cost of drug administration and RSV-related outcomes adjusted to 2010.

Table 3.  Health utilities incorporated in the cost-effectiveness model.

Figure 2.  Benchmark of palivizumab cost-effectiveness results with those of vaccines. AAP = American Academy of Pediatrics; DTaP = diptheris, tetanus, and acellular pertussis vaccine; HPV = human papillomavirus vaccine; RF = risk factor; TIV = trivalent inactivated influenza vaccine; wGA = weeks gestational age.

Figure 2.  Benchmark of palivizumab cost-effectiveness results with those of vaccines. AAP = American Academy of Pediatrics; DTaP = diptheris, tetanus, and acellular pertussis vaccine; HPV = human papillomavirus vaccine; RF = risk factor; TIV = trivalent inactivated influenza vaccine; wGA = weeks gestational age.

Table 4.  Net costs and QALYS between palivizumab prophylaxis and no prophylaxis among the 4 cohorts.

Table 5.  One-way sensitivity analysis for infants <32 wGA, ≤6 months CA.

Table 6.  One-way for infants 32–34 wGA, ≤3 months CA with 2009 AAP RF.

Table 7.  One-way for infants 32–35 wGA, ≤6 months CA with 2006 AAP RF.

Table 8.  One-way sensitivity analysis for infants 32–35 wGA, ≤6 months CA with ≤1 RF.

Figures 3 and 4.  Probabilistic analyses <32 wGA, ≤6 months CA. CA = chronologic age; QALY = quality-adjusted life-year; wGA = weeks gestational age.

Figures 3 and 4.  Probabilistic analyses <32 wGA, ≤6 months CA. CA = chronologic age; QALY = quality-adjusted life-year; wGA = weeks gestational age.

Figures 5 and 6.  Probabilistic analyses for 32–34 wGA, ≤3 months CA with AAP 2009 RF. AAP = American Academy of Pediatrics; CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

Figures 5 and 6.  Probabilistic analyses for 32–34 wGA, ≤3 months CA with AAP 2009 RF. AAP = American Academy of Pediatrics; CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

Figures 7 and 8.  Probabilistic analyses 32–35 wGA, ≤6 months CA with AAP 2006 RF. AAP = American Academy of Pediatrics; CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

Figures 7 and 8.  Probabilistic analyses 32–35 wGA, ≤6 months CA with AAP 2006 RF. AAP = American Academy of Pediatrics; CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

Figures 9 and 10.  Probabilistic analyses 32–35 wGA, ≤6 months CA with ≤1 RF. CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

Figures 9 and 10.  Probabilistic analyses 32–35 wGA, ≤6 months CA with ≤1 RF. CA = chronologic age; QALY = quality-adjusted life-year; RF = risk factor; wGA = weeks gestational age.

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