An incidence model of the cost of advanced prostate cancer in Spain

Figures & data

Figure 1. Graphical representation of the incident cost model.

Table 1. Key data used in the cost model.

Item	Value	Reference
Total number of incident cases of PCa in Spain in 2012	29,877	Sánchez et al.10
Percentage of total incident cases diagnosed with Stage III PCa	6.4%	Cozar et al.2
Percentage of total incident cases diagnosed with Stage IV PCa	3.8%	Cozar et al.2
Mean survival of Stage III PCa patients	Spanish male age-adjusted mortality rates	Instituto Nacional de Estadística17
Mean survival of Stage IV PCa patients	43.7 months	Stokes et al.8
Progression from Stage III to Stage IV PCa	50% after 10 years	Schoenstadt19
Change in consumer prices from January 2006 to January 2012	14.5%	Instituto Nacional de Estadística13
First-year cost of Stage III PCa	€3267	Fourcade et al.7
First-year cost of Stage IV PCa	€2513	Fourcade et al.7
Ratio between Initial and ongoing annual costs for Stage III	1.000:0.532	Wilson et al.14
Ratio between Initial and ongoing annual costs for Stage IV	1.000:0.532	Wilson et al.14
Estimated ongoing annual costs for Stage III	€1738	Fourcade et al.7, Wilson et al.14
Estimated ongoing annual costs for Stage IV	€1337	Fourcade et al.7, Wilson et al.14
Ratio between Initial and ongoing annual costs for Stage III	1.000:3.175	Yabroff et al.16
Ratio between Initial and ongoing annual costs for Stage IV	1.000:3.175	Yabroff et al.16
Estimated final costs for Stage III	€10,372	Fourcade et al.7, Yabroff et al.16
Estimated final year costs for Stage IV	€7978	Fourcade et al.7, Yabroff et al.16

Figure 2. Distribution of patients over time.

Figure 3. Results of sensitivity analysis: Tornado diagram—costs (€) per individual.

Table 2. Base case results: mean advanced PCa life-time costs.

Item	Stage III	Stage IV	Stage III + Stage IV
Initial number of patients (%)	1912 (63)	1135 (37)	3047 (100)
After 5 years (alive)	1207	2251	3993
After 10 years (alive)	703	2571	2200
After 15 years (alive)	352	2744	1113
Lifetime PCa costs (discounted at 3%)	€11,103	€8858	€19,961
Total lifetime costs for initial cohort of Stage III and Stage IV patients (discounted at 3%)	€33,835,142	€26,994,913	€60,830,055

Note: Some patients initially diagnosed as Stage III will progress to Stage IV over time.

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