Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder

Figures & data

Table I. Clinical correlates of neuron loss in Parkinson's disease. DA, dopamine; NA, noradrenaline; 5-HT, 5-hydroxytryptamine (serotonin); VP, vasopressin; Glu, glutamate; ACh, acetylcholine; CRF, corticotrophin-releasing factor; CCK, cholecystokinin; RBD, rapid eye movement (REM) sleep behavior disorder.

Table II. Genes implicated in familial Parkinson's disease. AD, autosomal dominant; AR, autosomal recessive; LB, Lewy body; DAT, dopamine transporter; TH, tyrosine hydroxylase.

Table III. Clinical correlates of striatal dopamine deficiency in Parkinson's disease.