Contribution of sleep research to the development of new antidepressants

Figures & data

Table I. Main effects of antidepressants on sleep. NS, not significant; HC, healthy control; MDD, major depressive disorder; REMS, rapid eye movement sleep; RL, REMS latency; SWS, slow-wave sleep; (+), slightly positive effect; +, positive effect; ++, marked positive effect; (-), slightly negative effect; -, negative effect; -, marked negative effect; MAOI, monoamine oxidase inhibitor; SSRI, selective serotonin reuptake inhibitor; NARI, noradrenaline reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; NaSSA, noradrenergic and specific serotonin reuptake antidepressant.