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Dialogues in Clinical Neuroscience Volume 9, 2007 - Issue 1
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Association study of T102C 5-HT2A polymorphism in schizophrenic patients: diagnosis, psychopathology, and suicidal behavior

Estudio de asociación del polimorfismo del gen T102C del receptor de serotonina 5-HT2A en pacientes esquizofrénicos: diagnóstico, psicopatología y conducta suicida

Etude d'association du polymorphisme T102C du gène codant pour le récepteur 5-HT2A chez les patients souffrant de schizophrénie: diagnostic, psychopathologie et comportement suicidaire

Humberto Correaa Department of Mental Health; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilCorrespondence[email protected]
,
Luiz De Marcob Department of Pharmacology; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
,
Wolfanga Bosonb Department of Pharmacology; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
,
Rodrigo Nicolatoc Pharmacogenetics Laboratory; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
,
Antó L. Teixeirac Pharmacogenetics Laboratory; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
,
Valdir R. Campoc Pharmacogenetics Laboratory; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
&
Marco A. Romano-Silvad Department of Pharmacology; Pharmacogenetics Laboratory; Serviço de Psiquiatria, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
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Pages 97-101 | Published online: 01 Apr 2022

Figures & data

Table I. Genotype distribution and demographic characteristics across schizophrenic patients and healthy controls. *: χ2=0.14, P=0.93; †: χ2=1,45, P=023; ‡: χ2=0.86, P=0.77

Table II. BPRS total scores and factor scores across genotypes in schizophrenic patients. BPRS, Brief Psychiatric Rating Scale. *: F=1.06, P=0.4; †: F=11.32, P=0.2; ‡: F=1.26, P=0.3; ║: F=0.5, P=0.88

Table III. Distribution of the 5-HT2A receptor gene 102 TC polymorphism in suicidal and nonsuicidal schizophrenic patients. BPRS, Brief Psychiatric Rating Scale. *: χ2=0.48, P=0.79; †: χ2=0.49, P=0.78; ‡: χ2=2.1, P=0.36; §: χ2=0.28, P=0,6; ║: χ2=0.46, P=0.5; ¶: χ2=0.42, P=0.52; #: F=0,54; P=0.6; **: F=0.57; P=0.57; ††: F=0.36; P=0.72

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