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Dialogues in Clinical Neuroscience Volume 11, 2009 - Issue 4
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Clinical Research

A new paradigm for the prediction of antidepressant treatment response

Un nuevo paradigma para predecir la respuesta al tratamiento antidepresivo

Un nouweau paradigme de prédiction de la réponse au traitement antidépresseur

Andrew F. LeuchterLaboratory of Brain Behavior, and Pharmacology, and the Depression Research and Clinical Program, Semel Institute for Neuroscience and Human Behavior at UCLA, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USACorrespondence[email protected]
,
Ian A. CookLaboratory of Brain Behavior, and Pharmacology, and the Depression Research and Clinical Program, Semel Institute for Neuroscience and Human Behavior at UCLA, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Aimee M. HunterLaboratory of Brain Behavior, and Pharmacology, and the Depression Research and Clinical Program, Semel Institute for Neuroscience and Human Behavior at UCLA, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
&
Alexander S. KorbLaboratory of Brain Behavior, and Pharmacology, and the Depression Research and Clinical Program, Semel Institute for Neuroscience and Human Behavior at UCLA, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Pages 435-446 | Published online: 01 Apr 2022

Figures & data

Figure 1. Study flow chart. Ham-D, Hamilton Depression Rating Scale; SSRI, selective serotonin reuptake inhibitor; EEG, electroencephalography
Figure 1. Study flow chart. Ham-D, Hamilton Depression Rating Scale; SSRI, selective serotonin reuptake inhibitor; EEG, electroencephalography
Figure 2. Receiver Operating Characteristic curve for ATR prediction of response to escitalopram treatment. ATR, Antidepressant Treatment Response index
Figure 2. Receiver Operating Characteristic curve for ATR prediction of response to escitalopram treatment. ATR, Antidepressant Treatment Response index
Figure 3. Logistic regression models of escitalopram and bupropion responders stratified by ATR values. ATR values of subjects randomly assigned to each treatment and who responded to escitalopram or bupropion treatment. Subjects who responded to escitalopram (blue) tended to have higher ATR values, and those who responded to bupropion (red) tended to have lower ATR values. Markers represent observed values and lines represent modeled values. ATR, Antidepressant Treatment Response index Adapted from ref 81: Leuchter AF, Cook IA, Gilmer WS, et ai. Effectiveness of a quantitative electroencephalographs biomarker for predicting differential response or remission with escitalopram and bupropion in Major Depressive Disorder. Psychiatry Res. 2009:169:124131. Copyright© Elsevier, 2009
Figure 3. Logistic regression models of escitalopram and bupropion responders stratified by ATR values. ATR values of subjects randomly assigned to each treatment and who responded to escitalopram or bupropion treatment. Subjects who responded to escitalopram (blue) tended to have higher ATR values, and those who responded to bupropion (red) tended to have lower ATR values. Markers represent observed values and lines represent modeled values. ATR, Antidepressant Treatment Response index Adapted from ref 81: Leuchter AF, Cook IA, Gilmer WS, et ai. Effectiveness of a quantitative electroencephalographs biomarker for predicting differential response or remission with escitalopram and bupropion in Major Depressive Disorder. Psychiatry Res. 2009:169:124131. Copyright© Elsevier, 2009
Figure 4. Logistic regression models of escitalopram and bupropion remitters stratified by ATR values. ATR values of subjects randomly assigned to each treatment and who remitted with escitalopram or bupropion treatment. Subjects who remitted with escitalopram (blue) tended to have higher ATR values, and those who remitted with bupropion (red) tended to have lower ATR values. Markers represent observed values and lines represent modeled values. ATR, Antidepressant Treatment Response index Adapted from ref 81: Leuchter AF, Cook IA, Gilmer WS, et al. Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in Major Depressive Disorder. Psychiatry Res. 2009:169:124131. Copyright © Elsevier, 2009
Figure 4. Logistic regression models of escitalopram and bupropion remitters stratified by ATR values. ATR values of subjects randomly assigned to each treatment and who remitted with escitalopram or bupropion treatment. Subjects who remitted with escitalopram (blue) tended to have higher ATR values, and those who remitted with bupropion (red) tended to have lower ATR values. Markers represent observed values and lines represent modeled values. ATR, Antidepressant Treatment Response index Adapted from ref 81: Leuchter AF, Cook IA, Gilmer WS, et al. Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in Major Depressive Disorder. Psychiatry Res. 2009:169:124131. Copyright © Elsevier, 2009

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