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Dialogues in Clinical Neuroscience Volume 18, 2016 - Issue 3
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Clinical Research

Genomic sequencing in clinical practice: applications, challenges, and opportunities

Secuenciación genómica en la práctica clínica: aplicaciones, desafíos y oportunidades

Applications, difficultés et opportunités du séquençage génomique en pratique clinique.

Joel B. Kriera Genomes2People Research Program, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USACorrespondence[email protected]
,
Sarah S. Kalia
&
Robert C. Greenb Genomes2People Research Program, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Pages 299-312 | Published online: 01 Apr 2022

Figures & data

Figure 1. Genomic sequencing use cases and suggested levels of evidence to demonstrate clinical utility. GS, genomic sequencing; PGx, pharmacogenomics. Adapted from ref 59: Delaney SK, Hultner ML, Jacob HJ, et al. Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Rev Mol Diagn. 2016;16(5):521-532. Copyright © Future Drugs, Ltd, 2016
Figure 1. Genomic sequencing use cases and suggested levels of evidence to demonstrate clinical utility. GS, genomic sequencing; PGx, pharmacogenomics. Adapted from ref 59: Delaney SK, Hultner ML, Jacob HJ, et al. Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Rev Mol Diagn. 2016;16(5):521-532. Copyright © Future Drugs, Ltd, 2016
Figure 2. A schematic of the workflow of clinical genomic sequencing.
Figure 2. A schematic of the workflow of clinical genomic sequencing.
Figure 3. Example of a MedSeq Genome Report (first page only).
Figure 3. Example of a MedSeq Genome Report (first page only).

TABLE I. Online genomic information resources. CME, continuing medical education; GWAS, genome-wide association study.

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