Biological markers of generalized anxiety disorder

Figures & data

Table I Summary of neuroimaging biomarkers in generalized anxiety disorder. (see abbreviations next page)

EtkinA.PraterKE.SchatzbergAF.et alDisrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder.Arch Gen Psychiatry.200966121361137219996041

 PubMed Web of Science ®Google Scholar

MakovacE.MeetenF.WatsonDR.et alNeurostructural abnormalities associated with axes of emotion dysregulation in generalized anxiety.Neuroimage Clin.20151017218126759791

 PubMed Web of Science ®Google Scholar

SchienleA.EbnerF.SchaferA.Localized gray matter volume abnormalities in generalized anxiety disorder.Eur Arch Psychiatry Clin Neurosci.2011261430330720820793

 PubMed Web of Science ®Google Scholar

LiaoM.YangF.ZhangY.et alChildhood maltreatment is associated with larger left thalamic gray matter volume in adolescents with generalized anxiety disorder.PLoS One.201388e7189823951265

 PubMed Web of Science ®Google Scholar

StrawnJR.WehryAM.ChuWJ.et alNeuroanatomic abnormalities in adolescents with generalized anxiety disorder: a voxel-based morphometry study.Depress Anxiety.201330984284823495075

 PubMed Web of Science ®Google Scholar

HilbertK.PineDS.MuehlhanM.et alGray and white matter volume abnormalities in generalized anxiety disorder by categorical and dimensional characterization.Psychiatry Res.2015234331432026490569

 PubMed Web of Science ®Google Scholar

MoonCM.JeongGW.Abnormalities in gray and white matter volumes associated with explicit memory dysfunction in patients with generalized anxiety disorder.Acta Radiol.201758335336127273376

 PubMed Web of Science ®Google Scholar

AbdallahCG.CoplanJD.JackowskiA.et alA pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD.Eur Neuropsychopharmacoi.2013234276284

 PubMed Web of Science ®Google Scholar

MonkCS.TelzerEH.MoggK.et alAmygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder.Arch Gen Psychiatry.200865556857618458208

 PubMed Web of Science ®Google Scholar

McClureEB.AdlerA.MonkCS.et alfMRI predictors of treatment outcome in pediatric anxiety disorders.Psychopharmacology (Berl).200719119710516972100

 PubMed Web of Science ®Google Scholar

NitschkeJB.SarinopoulosI.OathesDJ.et alAnticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response.Am J Psychiatry.2009166330231019122007

 PubMed Web of Science ®Google Scholar

EtkinA.PraterKE.HoeftF.et alFailure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder.Am J Psychiatry.2010167554555420123913

 PubMed Web of Science ®Google Scholar

YassaMA.HazlettRL.StarkCE.Hoehn-SaricR.Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder.J Psychiatr Res.20124681045105222575329

 PubMed Web of Science ®Google Scholar

BlairK.ShaywitzJ.SmithBW.et alResponse to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders.Am J Psychiatry.200816591193120218483136

 PubMed Web of Science ®Google Scholar

PaulesuE.SambugaroE.TortiT.et alNeural correlates of worry in generalized anxiety disorder and in normal controls: a functional MRI study.Psychol Med.201040111712419419593

 PubMed Web of Science ®Google Scholar

PalmME.ElliottR.McKieS.et alAttenuated responses to emotional expressions in women with generalized anxiety disorder.Psychol Med.20114151009101820716396

 PubMed Web of Science ®Google Scholar

BlairKS.GeraciM.SmithBW.et alReduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder.Biol Psychiatry.201272647648222592057

 PubMed Web of Science ®Google Scholar

BallTM.RamsawhHJ.Campbell-SillsL.et alPrefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders.Psychol Med.20134371475148623111120

 PubMed Web of Science ®Google Scholar

MoonCM.YangJC.JeongGW.Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder.J Affect Disord.201518632833626277269

 PubMed Web of Science ®Google Scholar

ChaJ.GreenbergT.CarlsonJM.et alCircuit-wide structural and functional measures predict ventromedial prefrontal cortex fear generalization: implications for generalized anxiety disorder.J Neurosci.201434114043405324623781

 PubMed Web of Science ®Google Scholar

ChaJ.CarlsonJM.DedoraDJ.et alHyper-reactive human ventral tegmental area and aberrant mesocorticolimbic connectivity in overgeneralization of fear in generalized anxiety disorder.J Neurosci.201434175855586024760845

 PubMed Web of Science ®Google Scholar

MonkCS.NelsonEE.McClureEB.et alVentrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder.Am J Psychiatry.200616361091109716741211

 PubMed Web of Science ®Google Scholar

WangW.HouJ.QianS.et alAberrant regional neural fluctuations and functional connectivity in generalized anxiety disorder revealed by resting-state functional magnetic resonance imaging.Neurosci Lett.2016624788427163197

 PubMed Web of Science ®Google Scholar

MakovacE.MeetenF.WatsonDR.et alAlterations in amygdalaprefrontal functional connectivity account for excessive worry and autonomic dysregulation in generalized anxiety disorder.Biol Psychiatry.2016801078679526682467

 PubMed Web of Science ®Google Scholar

StrawnJR.BitterSM.WeberWA.et alNeurocircuitry of generalized anxiety disorder in adolescents: a pilot functional neuroimaging and functional connectivity study.Depress Anxiety.2012291193994722628125

 PubMed Web of Science ®Google Scholar

CuiH.ZhangJ.LiuY.et alDifferential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder.Hum Brain Mapp.20163741459147326800659

 PubMed Web of Science ®Google Scholar

LiuWJ.YinDZ.ChengWH.et alAbnormal functional connectivity of the amygdala-based network in resting-state FMRI in adolescents with generalized anxiety disorder.Med Sci Monit.20152145946725673008

 PubMed Web of Science ®Google Scholar

WhalenPJ.JohnstoneT.SomervilleLH.et alA functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder.Biol Psychiatry .200863985886317964548

 PubMed Web of Science ®Google Scholar

NitschkeJB.SarinopoulosI.OathesDJ.et alAnticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response.Am J Psychiatry.2009166330231019122007

 PubMed Web of Science ®Google Scholar

MaslowskyJ.MoggK.BradleyBP.et alA preliminary investigation of neural correlates of treatment in adolescents with generalized anxiety disorder.J Child Adolesc Psychopharmacol.201020210511120415605

 PubMed Web of Science ®Google Scholar

FonzoGA.RamsawhHJ.FlaganTM.et alCognitive-behavioral therapy for generalized anxiety disorder is associated with attenuation of limbic activation to threat-related facial emotions.J Affect Disord.2014169768525171782

 PubMed Web of Science ®Google Scholar

BrownGG.OstrowitzkiS.SteinMB.et alTemporal profile of brain response to alprazolam in patients with generalized anxiety disorder.Psychiatry Res.2015233339440126211623

 PubMed Web of Science ®Google Scholar

Hoehn-SaricR.SchlundMW.WongSH.Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder.Psychiatry Res.20041311112115246451

 PubMed Web of Science ®Google Scholar

MaronE.KuikkaJT.UlstK.et alSPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder.Eur Arch Psychiatry Clin Neurosci.2004254639239615538601

 PubMed Web of Science ®Google Scholar

LeeLT.TsaiHC.ChiMH.et alLower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study.IntClin Psychopharmacol.2015303175178

 PubMed Web of Science ®Google Scholar

TiihonenJ.KuikkaJ.RasanenP.et alCerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis.Mol Psychiatry.1997264634719399689

 PubMed Web of Science ®Google Scholar

MathewSJ.MaoX.CoplanJD.et alDorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study.Am J Psychiatry.200416161119112115169704

 PubMed Web of Science ®Google Scholar

MathewSJ.PriceRB.ShunguDC.et alA pilot study of the effects of chronic paroxetine administration on hippocampal W-acetylaspartate in generalized anxiety disorder.J Psychopharmacol.20102481175118119204062

 PubMed Web of Science ®Google Scholar

MathewSJ.PriceRB.MaoX.et alHippocampal Ai-acetylaspartate concentration and response to riluzole in generalized anxiety disorder.Biol Psychiatry.200863989189818028881

 PubMed Web of Science ®Google Scholar

MoonCM.KangHK.JeongGW.Metabolic change in the right dorsolateral prefrontal cortex and its correlation with symptom severity in patients with generalized anxiety disorder: proton magnetic resonance spectroscopy at 3 Tesla.Psychiatry Clin Neurosci.201569742243025611853

 PubMed Web of Science ®Google Scholar