Assessing behavior and cognition in rodents, nonhuman primates, and humans: where are the limits of translation?


Figures & data

Figure 1. Translational behavioral and cognitive tests for major neurodevelopmental mental disorders. The figure lists the names of tests that can be applied in rodents, nonhuman primates, and humans to assess behaviors in the social, cognitive, and vigilance/sleep subdomains and in the negative and positive clinical symptom spectrum, as described in the main text. 
The need for an arrayed set of tests covering these behavioral subdomains is indicated by the shaded and colored bar graphs at the top of the figure, which shows the graded association with major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SZ). For detailed descriptions of the behavioral tests and references, see main text.