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Original Research Article

Osteitis in chronic rhinosinusitis: a histopathological study of human ethmoid bone remodeling in allergic versus non-allergic chronic rhinosinusitis

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Article: 23504 | Received 25 Oct 2013, Accepted 22 Nov 2013, Published online: 08 Jan 2014

Figures & data

Fig. 1 Descriptive histology of the ethmoid bone and nasal mucosa. (A) Control: thinner lamina propria with few vessels, thin trabeculae of mature lamellar bone, and a very thinned periosteum. (B) Allergic chronic rhinosinusitis (ACRS): mixed inflammatory cells infiltrating the lamina propria, including numerous eosinophils (black arrow), with thick periosteum around the lamellar bone (blue arrow). (C,D) Non-allergic chronic rhinosinusitis (NACRS): (C) severe inflammatory cells, predominantly lymphocytes and plasma cells (black arrow); and (D) osteoid bone interconnected haphazardly (red arrow) with osteoblastic rim (blue arrow) and focal osteoclastic activity (black arrow).

Fig. 2 The grading of osteitis in the different studied groups: (A) group I (control), (B) group II (NACRS), and (C) group III (ACRS). The y-axis demonstrates the number of patients, and the x-axis represents the grade of osteitis.

Fig. 3 (A) Correlation between mucosal grading and bone grading in allergic group; (B) correlation between mucosal grading and bone grading in non-allergic group.