Potency of pre–post treatment of coenzyme Q10 and melatonin supplement in ameliorating the impaired fatty acid profile in rodent model of autism

Figures & data

Table 1 Mean±SD together with the independent t-test for saturated fatty acid composition of brain tissue (Pg/ml) between neurointoxicated, protected, and therapeutically treated rat pups compared to healthy control

Saturated fatty acids	Control	PA	Melatonin+PPA	PA+Melatonin	CoQ+PA	PA+CoQ
Acetic	0.52±0.06	0.67±0.05	0.60±0.05	0.58±0.04	0.63±0.03	0.65±0.05
		0.001	0.013	ns	0.004	0.002
Propionic	1.23±0.16	1.97±0.36	1.63±0.09	1.51±0.10	1.56±0.11	1.64±0.06
		0.001	0.001	0.001	0.001	0.001
Butyric	0.54±0.13	0.89±0.09	0.82±0.05	0.84±0.08	0.82±0.13	0.89±0.12
		0.001	0.001	0.001	0.002	0.001
Valeric	0.13±0.02	0.22±0.02	0.21±0.02	0.21±0.02	0.21±0.03	0.24±0.03
		0.001	0.001	0.001	0.001	0.001
Hexanoic	1.73±0.20	1.96±0.12	1.84±0.17	1.85±0.12	1.74±0.13	1.79±0.19
		0.019	ns	ns	ns	ns
Caprylic	1.47±0.19	2.22±0.14	2.06±0.12	2.10±0.13	1.88±0.10	2.05±0.22
		0.001	0.001	0.001	0.001	0.001
Decanoic	1.21±0.16	1.75±0.14	1.62±0.16	1.48±0.12	1.41±0.11	1.53±0.06
		0.001	0.001	0.002	0.024	0.001
Lauric	1.01±0.21	1.65±0.12	1.63±0.15	1.84±0.14	1.80±0.12	1.80±0.12
		0.001	0.001	0.001	0.001	0.001
Myristic	1.20±0.13	1.42±0.12	1.20±0.12	1.20±0.10	1.20±0.11	1.29±0.09
		0.003	ns	ns	ns	ns
Palmitic	0.76±0.11	1.07±0.10	1.02±0.12	1.01±0.09	1.00±0.19	1.10±0.15
		0.001	0.001	0.001	0.027	0.001
Heptadecanoic	0.96±0.17	1.38±0.12	1.30±0.14	1.17±0.10	1.23±0.14	1.31±0.15
		0.001	0.001	0.010	0.007	0.001
Stearic	1.16±0.20	1.59±0.13	1.39±0.13	1.35±0.11	1.24±0.13	1.32±0.10
		0.001	0.013	0.032	ns	ns
Arachidic	0.45±0.12	0.48±0.05	0.47±0.05	0.54±0.06	0.57±0.03	0.61±0.04
		ns	ns	ns	0.019	0.005
Behenic	0.31±0.05	0.50±0.03	0.48±0.05	0.56±0.03	0.64±0.02	0.67±0.04
		0.001	0.001	0.001	0.001	0.001
Lignoceric	0.25±0.03	0.38±0.03	0.38±0.04	0.45±0.03	0.51±0.02	0.57±0.06
		0.001	0.001	0.001	0.001	0.001

Table 2 Mean±SD together with the independent t-test for unsaturated fatty acid composition of brain tissue (Pg/ml) between neurointoxicated, protected, and therapeutically treated rat pups compared to healthy control.

Unsaturated fatty acids	Control	PA	Melatonin+PA	PA+Melatonin	CoQ+PA	PA+CoQ
α-Linolenic	0.41±0.07	0.31±0.02	0.31±0.03	0.37±0.02	0.42±0.03	0.46±0.03
		0.004	0.002	ns	ns	ns
Stearidonic	0.20±0.04	0.45±0.04	0.41±0.04	0.38±0.03	0.40±0.03	0.46±0.04
		0.001	0.001	0.001	0.001	0.001
Linoleic	0.29±0.05	0.47±0.04	0.52±0.05	0.57±0.05	0.57±0.11	0.63±0.09
		0.001	0.001	0.001	0.001	0.001
γ-Linolenic	0.43±0.06	0.14±0.01	0.17±0.02	0.18±0.01	0.22±0.02	0.24±0.04
		0.001	0.001	0.001	0.001	0.001
Oleic	0.74±0.09	0.62±0.04	0.57±0.05	0.52±0.03	0.51±0.05	0.50±0.05
		0.004	0.001	0.001	0.001	0.001
Eicosapentaenoic	0.43±0.04	0.37±0.03	0.42±0.03	0.32±0.03	0.38±0.04	0.39±0.05
		0.006	ns	0.001	0.031	ns
Arachidonic	0.38±0.04	0.31±0.03	0.43±0.04	0.37±0.04	0.38±0.04	0.42±0.03
		0.001	ns	ns	ns	ns
Docosahexaenoic	0.64±0.07	0.53±0.05	0.64±0.06	0.51±0.04	0.52±0.08	0.54±0.09
		0.001	ns	0.001	0.006	0.029