Hepatitis B and C viruses and survival from hepatocellular carcinoma in the Arkhangelsk region: a Russian registry-based study

Figures & data

Fig. 1 Sample description.

Table I Socio-demographic and basic clinical characteristics of HCC patients in the Arkhangelsk region in 2000–2008 by their viral status

		Proportion of patients with viral hepatitis, % (n = 194)
Characteristics	Proportion of virus-free patients, % (n = 117)	HBV (n = 124)	HCV (n = 54)	HBV and HCV (n = 16)	p*
Gender
Male	73 (62.4%)	65 (52.4%)	35 (64.8%)	8 (50.0%)	0.266
Female	44 (37.6%)	59 (47.6%)	19 (35.2%)	8 (50.0%)
Age (years)
< 60	25 (21.4%)	20 (16.1%)	5 (9.3%)	5 (31.3%)	0.491
60–69	17 (14.5%)	21 (16.9%)	9 (16.7%)	3 (18.8%)
70–79	39 (33.3%)	43 (34.7%)	24 (44.4%)	6 (37.5%)
80 and above	36 (30.8%)	40 (32.3%)	16 (29.6%)	2 (12.5%)
HCC stage
Data not available	11 (9.4%)	22 (17.7%)	8 (14.8%)	5 (31.3%)
I	15 (12.8%)	8 (6.5%)	5 (9.3%)	1 (6.3%)	0.117
II	16 (13.7%)	10 (8.1%)	2 (3.7%)	0 (0.0%)
III	34 (29.1%)	34 (27.4%)	14 (25.9%)	2 (12.5%)
IV	41 (35.0%)	50 (40.3%)	25 (26.3%)	8 (50.0%)
Cirrhosis stage
No cirrhosis	65 (55.6%)	45 (36.3%)	33 (61.1%)	7 (43.8%)	<0.0001
Child A	37 (31.6%)	35 (28.2%)	5 (9.3%)	4 (25.0%)
Child B	14 (12.0%)	26 (21.0%)	9 (16.7%)	3 (18.8%)
Child C	1 (0.9%)	18 (14.5%)	7 (13.0%)	2 (12.5%)

* Calculated using Pearson's Chi-squared test.

Fig. 2 Survival of HCC patients in the Arkhangelsk region in 2000–2008 by their viral status. Data show that non-infected HCC patients have more survival time compared with patients infected with viral hepatitis B and C virus.

Table II Crude and adjusted hazard ratio for survival of HCC patients in the Arkhangelsk region in 2000–2008 by their viral status

		95% CI			95% CI
Factors	HR crude	Lower	Upper	HR adjusted^a	Lower	Upper
Viral status
Virus-free	1.00	Reference	Reference	1.00	Reference	Reference
HBV-infected	1.43	1.07	1.91	1.13	0.83	1.53
HCV-infected	1.34	0.93	1.93	1.04	0.71	1.52
HBV- and HCV-infected	1.89	1.09	3.27	2.10	1.16	3.78

a Adjusted for sex, age groups, cirrhosis stage and stage of HCC.