Attenuation of Candida albicans virulence with focus on disruption of its vacuole functions

Figures & data

Fig 1.  Assembly and trafficking of the yeast V-ATPase. Possible steps in assembly and transport of Vph1p- and Stv1p-containing V-ATPases are shown. Shading of different organelles indicates extent of acidification; the vacuole is most intensely colored as the most acidic compartment in the yeast cell. The first compartment in the secretory pathway showing evidence of acidification is the Golgi apparatus. Vph1p-containing V-ATPases are known to travel to the vacuole via the prevacuolar compartment and are believed to reach this compartment via the early endosome, which is also likely to be somewhat acidic. Stv1p-containing V-ATPases appear to cycle between the prevacuolar compartment and the vacuole, and may also travel through the early endosome. The RAVE complex assists in reassembly of the V₁ and V₀ complexes at the vacuole, and possibly in assembly at the early endosome. Modified from9.

Kane PM. The where, when, and how of organelle acidification by the yeast vacuolar ATPase. Microbiol Mol Biol Rev. 2006; 70: 28872–81.

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