Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer

Figures & data

Figure 1.  Normal colonic tissue with positive VEGF immunostaining, score 2.

Table 1. VEGF overexpression in relation to grade and stage of colorectal carcinoma

Pathological parameters	VEGF positive	VEGF negative	Total	p-Value
Non-cancerous	4 (18.2%)	18 (81.8)	22 (29.7%)	<0.05 R=0.81
Malignant	27 (51.9%)	25 (48.1%)	52 (70.3%)
Adenocarcinoma	26 (52%)	24 (48%)	50 (96.2%)
Squamous carcinoma	1 (50%)	1 (50%)	2 (3.8%)
Grade
Grade 1	9 (47.4%)	10 (56.6%)	19 (36.5%)	<0.05 R=0.96
Grade 2	11 (52.4%)	10 (47.6%)	21 (40.4%)
Grade 3	7 (58.3%)	5 (41.7%)	12 (23%)
TNM stage
I	7 (53.8%)	6 (46.2%)	13 (25%)	>0.05 R=0.05
II	11 (52.4%)	10 (47.6%)	21 (40.4%)
III	9 (50%)	9 (50%)	18 (34.6%)

Figure 2.  Squamous cell carcinoma of rectum, grade II exhibiting positive faint, score 1 VEGF immunostaining.

Figure 3.  Adenocarcinoma of colon, grade I, stage II with positive dense VEGF immunostaining, score 4 (×10).

Table 2. Intensity of vascular endothelial growth factors in relation to grade, stage and pattern of immunostaining in colorectal carcinoma

Intensity of stain	Score 0	Score +1	Score +2	Score +3	Score +4	Total
Grade
I	10 (50%)	3 (15%)	2 (1%)	4 (20%)	1 (0.5%)	20 (38.46%)
II	10 (47.6%)	6 (28.6%)	5 (23.81%)	0 (0%)	0 (0%)	21 (40.4%)
III	5 (45.6%)	4 (36.4%)	2 (18%)	0 (0%)	0 (0%)	11 (21.15%)
	p<0.05	R=0.96
Stage
I	6 (42.9%)	5 (35.7%)	2 (14.3%)	1 (7.1%)	0 (0%)	14 (26.9%)
II	10 (47.6%)	4 (19%)	3 (14.1%)	3 (14.1%)	1 (4.2%)	21 (40.4%)
III	9 (50%)	5 (2.7%)	3 (15.8%)	1 (5.6%)	0 (0%)	17 (32.7%)
	p<0.05	R=0.62
Pattern
Faint	0 (0%)	8 (72.7%)	2 (18.2%)	1 (9%)	0 (0%)	11 (40.7%)
Dense	0 (0%)	6 (36.5%)	6 (36.5%)	3 (18.8%)	1 (6.3%)	16 (59.3%)
	p<0.05	R=0.95