Leukocytosis as a prognostic marker in the development of fetal inflammatory response syndrome

Figures & data

Table 1. Comparison of the number of leukocytes in maternal blood

The number of leukocytes	FIRS group n = 52	Control group n = 106	p ^†
before labor (×10^9/L)
Mean±SD	13.20±4.80	11.24±3.14
Median	12.74	11.43	0.034
[min – max]	[6.53–25.52]	[3.62–25.46]
during labor (×10^9/L)
Mean±SD	14.04±4.80	11.3±3.74
Median	13.31	11.61	0.004
[min – max]	[6.53–25.34]	[5.73–26.30]
after labor (×10^9/L)
Mean±SD	12.93±4.64	12.12±3.73
Median	12.23	11.65	0.565
[min – max]	[6.73–24.88]	[5.73–25.46]

>† Mann–Whitney test; FIRS, fetal inflammatory response syndrome; SD, standard deviation.

Significant values are set in bold.

Figure 1 ROC curves analysis for determining the critical values of leukocytes in maternal blood before labor.

Figure 2 ROC curves analysis for determining the critical values of leukocytes in maternal blood during labor.

Table 2. The critical values of leukocytes in maternal blood for predicting the development of fetal inflammatory response syndrome

The number of leukocytes	Critical value (×10^9/L)	Sensitivity (%)	Specificity (%)	95% CI	AUC	PPV (%)	NPV (%)
Before labor	11.81	56.3	58.3	0.5030–0.7118	0.6074	74.1	38.6
During labor	12.64	60.4	62.1	0.5454–0.7467	0.6460	77.1	42.6
After labor	12.05	52.1	53.4	0.4245–0.6338	0.5291	70.5	34.2

CI, confidence Interval; AUC, area under the ROC curve; PPV, positive predictive value; NPV, negative predictive value.

Table 3. Correlation between the number of leukocytes in maternal blood and concentrations of cytokines in umbilical cord blood

	Spearman correlation coefficient, r (p value)
The number of leukocytes	IL-6	TNF-α
before labor	0.1 (0.1)	0.2 (0.02)
during labor	0.2 (0.05)	0.2 (0.007)
after labor	−0.04 (0.6)	0.1 (0.1)

Significant values are set in bold.