Prevalence of hemoglobin variants in a diabetic population at high risk of hemoglobinopathies and optimization of HbA1c monitoring by incorporating HPLC in the laboratory workup

Figures & data

Fig. 1 Chromatograms from samples of diabetic patients without and with hemoglobin variants (HPLC D-10). (a) sample without hemoglobin variant; (b) sample with HbS; (c) sample with HbC; (d) sample with hemoglobin variant not recognized.

Fig. 2 Procedure and interpretation of HbA1c result on cation-exchange HPLC analyzer in the presence of hemoglobin variant.