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Original Articles

Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated Escherichia coli and Bacillus cereus on holoxenic mice

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Article: 23239 | Received 31 Oct 2013, Accepted 16 Jun 2014, Published online: 22 Sep 2014

Figures & data

Fig. 1 Graphic representation of IL-12 concentration in the serum of holoxenic mice, collected after: I – 7 days from the first oral administration of NVCs; II – 14 days from the first oral administration of NVCs; III – 21 days from the first oral administration of NVCs. IC, integral culture; CS, cellular suspension; SN, supernatant; A, serum collected from holoxenic mice after oral administration of NVC; B, serum collected from holoxenic mice after oral administration of NVC stimulated with E. coli O28C; C, serum collected from holoxenic mice after oral administration of NVC stimulated with B. cereus; MC, media control – serum collected from holoxenic mice after oral administration of MRS; NC, negative control – serum collected from holoxenic mice control.

Fig. 1 Graphic representation of IL-12 concentration in the serum of holoxenic mice, collected after: I – 7 days from the first oral administration of NVCs; II – 14 days from the first oral administration of NVCs; III – 21 days from the first oral administration of NVCs. IC, integral culture; CS, cellular suspension; SN, supernatant; A, serum collected from holoxenic mice after oral administration of NVC; B, serum collected from holoxenic mice after oral administration of NVC stimulated with E. coli O28C; C, serum collected from holoxenic mice after oral administration of NVC stimulated with B. cereus; MC, media control – serum collected from holoxenic mice after oral administration of MRS; NC, negative control – serum collected from holoxenic mice control.

Fig. 2 Graphic representation of TNF α concentration in the serum of holoxenic mice, collected after: I – 7 days from the first oral administration of NVCs; II – 14 days from the first oral administration of NVCs; III – 21 days from the first oral administration of NVCs. IC, integral culture, CS, cellular suspension; SN, supernatant; A, serum collected from holoxenic mice after oral administration of NVC; B, serum collected from holoxenic mice after oral administration of NVC stimulated with E. coli O28C; C, serum collected from holoxenic mice after oral administration of NVC stimulated with B. cereus; MC, media control – serum collected from holoxenic mice after oral administration of MRS; NC, negative control – serum collected from holoxenic mice control.

Fig. 2 Graphic representation of TNF α concentration in the serum of holoxenic mice, collected after: I – 7 days from the first oral administration of NVCs; II – 14 days from the first oral administration of NVCs; III – 21 days from the first oral administration of NVCs. IC, integral culture, CS, cellular suspension; SN, supernatant; A, serum collected from holoxenic mice after oral administration of NVC; B, serum collected from holoxenic mice after oral administration of NVC stimulated with E. coli O28C; C, serum collected from holoxenic mice after oral administration of NVC stimulated with B. cereus; MC, media control – serum collected from holoxenic mice after oral administration of MRS; NC, negative control – serum collected from holoxenic mice control.