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Review articles

Zinc, aging, and immunosenescence: an overview

Article: 25592 | Received 29 Jul 2014, Accepted 09 Dec 2014, Published online: 05 Feb 2015

Figures & data

Fig. 1 Homeostasis of zinc.

Fig. 1 Homeostasis of zinc.

Fig. 2 Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.

Fig. 2 Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.