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Review Articles

Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy

Article: 32221 | Received 10 May 2016, Accepted 29 Jul 2016, Published online: 23 Aug 2016

Figures & data

Fig. 1 Summary of cardiomyocyte fatty acid metabolism in healthy hearts.

Fig. 1 Summary of cardiomyocyte fatty acid metabolism in healthy hearts.

Fig. 2 Cardiac lipotoxicity contributes to cardiac aging by promoting formation of toxic lipids, ceramides (Cer), and diacylglycerols (DAGs) that compromise β-AR function and by causing mitochondrial dysfunction.

Fig. 2 Cardiac lipotoxicity contributes to cardiac aging by promoting formation of toxic lipids, ceramides (Cer), and diacylglycerols (DAGs) that compromise β-AR function and by causing mitochondrial dysfunction.