Figures & data
Figure 1. Synthetic and degradation pathways of nitric.
Nitric oxide is synthesized, along with citrulline, from L-arginine by nitric oxide synthase. L-arginine may be proteolyzed to form methylarginines (ADMA and L-NMMA), which in turn inhibit NOS activity by competing with arginine at the active site. Methylarginines are metabolized by dimethyl-arginine-dimethyl-aminohydrolase (DDAH) into citrulline and dimethylarginine. Citrulline can be converted back to arginine by enzymes of the urea cycle [Citation25].
NOS: Nitric oxide synthase;
DDAH: dimethyl-arginine-dimethyl-aminohydrolase.
![Figure 1. Synthetic and degradation pathways of nitric.Nitric oxide is synthesized, along with citrulline, from L-arginine by nitric oxide synthase. L-arginine may be proteolyzed to form methylarginines (ADMA and L-NMMA), which in turn inhibit NOS activity by competing with arginine at the active site. Methylarginines are metabolized by dimethyl-arginine-dimethyl-aminohydrolase (DDAH) into citrulline and dimethylarginine. Citrulline can be converted back to arginine by enzymes of the urea cycle [Citation25].NOS: Nitric oxide synthase;DDAH: dimethyl-arginine-dimethyl-aminohydrolase.](/cms/asset/1bd886f5-01a2-4d11-a306-aa83dae245a1/ifso_a_12363799_f0001.jpg)