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Research Article

The Effect of Concentrated Growth Factors in the Treatment of Periodontal Intrabony Defects

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Article: FSO136 | Accepted 13 May 2016, Published online: 15 Sep 2016

Figures & data

Figure 1. Concentrated growth factors.

(A) Three blood fractions were obtained through centrifuge process (1) a superior phase represented by the serum; (2) an interim phase represented by a very large and dense polymerized fibrin block containing the CGFs, white blood cells and stem cells; and (3) the lower red blood cell layer. (B) CGFs separated from platelet-poor plasma.

Figure 1.  Concentrated growth factors.(A) Three blood fractions were obtained through centrifuge process (1) a superior phase represented by the serum; (2) an interim phase represented by a very large and dense polymerized fibrin block containing the CGFs, white blood cells and stem cells; and (3) the lower red blood cell layer. (B) CGFs separated from platelet-poor plasma.

Figure 2. (A) An example in the experimental group: the second right mandibular premolar, baseline. (B) Intra-surgical findings. (C) Mixture of CGFs and BPBM granules was placed into the defect. (D) CGFs membrane was placed. (E) Flap sutured. (F) 1 year post-surgery.

Figure 2.  (A) An example in the experimental group: the second right mandibular premolar, baseline. (B) Intra-surgical findings. (C) Mixture of CGFs and BPBM granules was placed into the defect. (D) CGFs membrane was placed. (E) Flap sutured. (F) 1 year post-surgery.

Figure 3. Radiographic landmarks.

AC: Alveolar crest; BD: Base of the defect; CEJ: Cemento–enamel junction.

Figure 3.  Radiographic landmarks.AC: Alveolar crest; BD: Base of the defect; CEJ: Cemento–enamel junction.

Figure 4. Periapical radiograph of the second right mandibular premolar 1 year post-surgery.

Figure 4.  Periapical radiograph of the second right mandibular premolar 1 year post-surgery.

Table 1. Distribution and type of treated intrabony defects.

Table 2. Mean intrabony defect characteristics in surgery.

Table 3. Mean plaque index and bleeding index at baseline and 1 year post surgery.

Table 4. Clinical parameters at baseline and 1 year post surgery.

Table 5. Number of sites and percentage of clinical attachment level gain ≥3 mm in test and control groups.

Table 6. Mean radiographic measurements of test and control groups.

Table 7. The levels of growth factors in platelet poor plasma and concentrated growth factors.