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Future Science OA Volume 3, 2017 - Issue 1
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Research Article

Horizontal Alignment of 5′ -> 3′ Intergene Distance Segment Tropy with Respect to the Gene as the Conserved Basis for DNA Transcription

Hemant Sarin1 Freelance Investigator in Translational Science & Medicine (unaffiliated), 833 Carroll Road, Charleston, WV25314, USACorrespondence[email protected]
Article: FSO160 | Received 23 Dec 2016, Accepted 31 Oct 2016, Published online: 02 Dec 2016

Figures & data

Figure 1.  >11,864 ≤265,005 gene base category, SORL1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 1.  >11,864 ≤265,005 gene base category, SORL1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 2.  >11,864 ≤265,005 gene base category, PDPN, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 2.  >11,864 ≤265,005 gene base category, PDPN, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 3.  >11,864 ≤265,005 gene base category, BTG1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Filled green square, first non-mono anisotropic point (95,217, 4,153) of the second ASEBS (419,487, 57,054) shown without the non-mono anisotropic point (95,217, 4,153); green star, immediately preceding 3′ -> 5′ reverse anisotropic point 78, 93,666.

Figure 3.  >11,864 ≤265,005 gene base category, BTG1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.Filled green square, first non-mono anisotropic point (95,217, 4,153) of the second ASEBS (419,487, 57,054) shown without the non-mono anisotropic point (95,217, 4,153); green star, immediately preceding 3′ -> 5′ reverse anisotropic point 78, 93,666.

Figure 4.  >11,864 ≤265,005 gene base category, HAPLN1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 4.  >11,864 ≤265,005 gene base category, HAPLN1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 5.  >11,864 ≤265,005 gene base category, MRC1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 5.  >11,864 ≤265,005 gene base category, MRC1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 6.  >11,864 ≤265,005 gene base category, ACPP, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sum split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Filled green square, non-mono anisotropic not considered (NC) first sub-episode block (SEB) (NC ASEBS 26,865, 1,099) due to six preceding 3′-> 5′ reverse anisotropic points of greater magnitude (Green stars), in which case the 0 order prpTQ SEB (first considered SEB) is the immediately following SEB, a mesotropic SEB.

Figure 6.  >11,864 ≤265,005 gene base category, ACPP, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sum split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.Filled green square, non-mono anisotropic not considered (NC) first sub-episode block (SEB) (NC ASEBS 26,865, 1,099) due to six preceding 3′-> 5′ reverse anisotropic points of greater magnitude (Green stars), in which case the 0 order prpTQ SEB (first considered SEB) is the immediately following SEB, a mesotropic SEB.

Figure 7.  >11,864 ≤265,005 gene base category, TGFA, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sum split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 7.  >11,864 ≤265,005 gene base category, TGFA, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sum split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 8.  >11,864 ≤265,005 gene base category, PHLPP1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 8.  >11,864 ≤265,005 gene base category, PHLPP1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 9.  >11,864 ≤265,005 gene base category, SELE, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 9.  >11,864 ≤265,005 gene base category, SELE, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 10.  >11,864 ≤265,005 gene base category, CDH11, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 10.  >11,864 ≤265,005 gene base category, CDH11, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 11.  >11,864 ≤265,005 gene base category, ZCCHC2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 11.  >11,864 ≤265,005 gene base category, ZCCHC2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 2.

Figure 12.  ≤11,864 gene base category, S100A2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 12.  ≤11,864 gene base category, S100A2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 13.  ≤11,864 gene base category, PRR3, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 13.  ≤11,864 gene base category, PRR3, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 14.  ≤11,864 gene base category, IFI27, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 14.  ≤11,864 gene base category, IFI27, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 15.  ≤11,864 gene base category, S100A14, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 15.  ≤11,864 gene base category, S100A14, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 3.

Figure 16.  >265,005 <607,463 gene base category, ABCB1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 4.

Figure 16.  >265,005 <607,463 gene base category, ABCB1, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 4.

Figure 17.  ≥607,463 <2,241,933 gene base category, FOXP2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 5.

Figure 17.  ≥607,463 <2,241,933 gene base category, FOXP2, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 5.

Figure 18.  ≥2,241,933 gene base category, DMD, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 6.

Filled green squares with yellow border interconnected by arrowed line, 3′ -> 5′ reverse isotropy point (253,856, 280,037) of the tempered considered (TC) first MSEBS upstream intergene distance 0.125-factor adjusted to 31,732, 31,732 instead of upstream intergene distance 0.25-factor adjusted to 63,464, 63,464 as there are two immediately preceding reverse anisotropy points (167,442, 830,657; 5,488, 272,663) of sufficient 3′ -> 5′ reverse anisotropy (Green stars) to diminish the 3′ -> 5′ reverse isotropy stabilizing effect of 253,856, 280,037 to 31,732, 31,732; Filled blue square with yellow border, first MSEBS with 0.125-factor adjusted 31,732, 31,732 point.

Figure 18.  ≥2,241,933 gene base category, DMD, sub-episode block sums (MSEBS; ASEBS) and the final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) @ Episode 6.Filled green squares with yellow border interconnected by arrowed line, 3′ -> 5′ reverse isotropy point (253,856, 280,037) of the tempered considered (TC) first MSEBS upstream intergene distance 0.125-factor adjusted to 31,732, 31,732 instead of upstream intergene distance 0.25-factor adjusted to 63,464, 63,464 as there are two immediately preceding reverse anisotropy points (167,442, 830,657; 5,488, 272,663) of sufficient 3′ -> 5′ reverse anisotropy (Green stars) to diminish the 3′ -> 5′ reverse isotropy stabilizing effect of 253,856, 280,037 to 31,732, 31,732; Filled blue square with yellow border, first MSEBS with 0.125-factor adjusted 31,732, 31,732 point.

Table 1.  Episodic and sub-episodic block character as per the paired point tropy quotients (prpTQs).

Table 2.  Final episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ) per gene category.

Supplemental material

Supplementary Material For: Supplementary file 1 - Table S1. Selection of genes differentially overexpressed for analysis

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Supplementary Material For: Table S2. Intergene distances with tropy pairing and paired gene overexpression tropy quotients (prpT Qs) for respective episodes per gene category

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Supplementary Material For: Supplementary file 3 - Table S3. Sequential episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotients (esebssiwaagoTQs) to final esebssiwaagoTQ

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